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• W2002087021 abstract "Down syndrome (DS) is generally considered as an “atheroma-free model”. In this preliminary study, we investigated homocysteine, folate and Vitamin B12 levels in 13 DS patients (male, average age 60 years) and 20 age-matched individuals. We also studied lipid fractions, and polymorphisms for Cystothionine β-synthase (CBS), 5,10-methyl-tetrahydro-folate reductase (MTHFR) and apolipoprotein E (Apo-E) genes. However, DS patients with the MTHFR TT genotype showed an increased of plasma homocysteine (tHcy). Our results indicate that this group of “healthy old” Down syndrome patients, although showing some classical biochemical risk factors for atherosclerosis, did not suffer clinical cardiovascular alterations." @default.
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• W2002087021 date "2006-11-01" @default.
• W2002087021 modified "2023-10-16" @default.
• W2002087021 title "Does Down's syndrome support the homocysteine theory of atherogenesis?" @default.
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• W2002087021 doi "https://doi.org/10.1016/j.archger.2006.01.003" @default.
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