FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002088207> ?p ?o ?g. }

• W2002088207 endingPage "168" @default.
• W2002088207 startingPage "159" @default.
• W2002088207 abstract "The development of the lens is dependent on the proliferation of lens epithelial cells and their differentiation into fiber cells near the lens bow/equator. Identification of genes specifically expressed in the lens epithelial cells and their functions may provide insight into molecular events that regulate the processes of lens epithelial cell differentiation. In this study, a novel lens epithelium gene product, LEP503, identified from rat by a subtractive cDNA cloning strategy was investigated in the genome organization, mRNA expression and protein localization. The genomic sequences for LEP503 isolated from rat, mouse and human span 1754 bp, 1694 bp and 1895 bp regions encompassing the 5′-flanking region, two exons, one intron and 3′-flanking region. All exon-intron junction sequences conform to the GT/AG rule. Both mouse and human LEP503 genes show very high identity (93% for mouse and 79% for human) to rat LEP503 gene in the exon 1 that contains an open reading frame coding for a protein of 61 amino acid residues with a leucine-rich domain. The deduced protein sequences also show high identity (91% between mouse and rat and 77% between human and rat). Western blot shows that LEP503 is present as a specific ∼6.9 kDa band in the water-insoluble-urea-soluble fraction of lens cortex where lens epithelium is included. Immuno-staining shows that LEP503 is localized in the epithelial cells along the entire anterior surface of rat lens. Developmentally, LEP503 is expressed at a low level at newborn, and then the expression level increases by about ten-fold around postnatal day 14 and remains at this high level for about 25 days before it drops back to the low level by postnatal day 84. These data suggest that the LEP503 may be an important lens epithelial cell gene involving the processes of epithelial cell differentiation." @default.
• W2002088207 created "2016-06-24" @default.
• W2002088207 creator A5057185561 @default.
• W2002088207 creator A5062556828 @default.
• W2002088207 creator A5079458857 @default.
• W2002088207 date "2000-02-01" @default.
• W2002088207 modified "2023-10-16" @default.
• W2002088207 title "A Novel Lens Epithelium Gene, LEP503, is Highly Conserved in Different Vertebrate Species and is Developmentally Regulated in Postnatal Rat Lens" @default.
• W2002088207 cites W1262514376 @default.
• W2002088207 cites W1739497080 @default.
• W2002088207 cites W1963595009 @default.
• W2002088207 cites W1980473808 @default.
• W2002088207 cites W1982589114 @default.
• W2002088207 cites W1996797924 @default.
• W2002088207 cites W1998452269 @default.
• W2002088207 cites W2001060745 @default.
• W2002088207 cites W2001730018 @default.
• W2002088207 cites W2004660647 @default.
• W2002088207 cites W2032462163 @default.
• W2002088207 cites W2034482399 @default.
• W2002088207 cites W2036165251 @default.
• W2002088207 cites W2049661143 @default.
• W2002088207 cites W2072071819 @default.
• W2002088207 cites W2074285728 @default.
• W2002088207 cites W2076609051 @default.
• W2002088207 cites W2095886901 @default.
• W2002088207 cites W2108317548 @default.
• W2002088207 cites W2108388593 @default.
• W2002088207 cites W2115333784 @default.
• W2002088207 cites W2118382847 @default.
• W2002088207 cites W2169913534 @default.
• W2002088207 cites W2173218272 @default.
• W2002088207 cites W2404947585 @default.
• W2002088207 cites W2576734941 @default.
• W2002088207 cites W4294216491 @default.
• W2002088207 doi "https://doi.org/10.1006/exer.1999.0770" @default.
• W2002088207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10655141" @default.
• W2002088207 hasPublicationYear "2000" @default.
• W2002088207 type Work @default.
• W2002088207 sameAs 2002088207 @default.
• W2002088207 citedByCount "6" @default.
• W2002088207 countsByYear W20020882072012 @default.
• W2002088207 countsByYear W20020882072022 @default.
• W2002088207 crossrefType "journal-article" @default.
• W2002088207 hasAuthorship W2002088207A5057185561 @default.
• W2002088207 hasAuthorship W2002088207A5062556828 @default.
• W2002088207 hasAuthorship W2002088207A5079458857 @default.
• W2002088207 hasConcept C104317684 @default.
• W2002088207 hasConcept C151730666 @default.
• W2002088207 hasConcept C15336307 @default.
• W2002088207 hasConcept C153911025 @default.
• W2002088207 hasConcept C167625842 @default.
• W2002088207 hasConcept C187882448 @default.
• W2002088207 hasConcept C189482833 @default.
• W2002088207 hasConcept C196436469 @default.
• W2002088207 hasConcept C2909221355 @default.
• W2002088207 hasConcept C36823959 @default.
• W2002088207 hasConcept C47289529 @default.
• W2002088207 hasConcept C54355233 @default.
• W2002088207 hasConcept C86803240 @default.
• W2002088207 hasConcept C94671646 @default.
• W2002088207 hasConcept C95444343 @default.
• W2002088207 hasConceptScore W2002088207C104317684 @default.
• W2002088207 hasConceptScore W2002088207C151730666 @default.
• W2002088207 hasConceptScore W2002088207C15336307 @default.
• W2002088207 hasConceptScore W2002088207C153911025 @default.
• W2002088207 hasConceptScore W2002088207C167625842 @default.
• W2002088207 hasConceptScore W2002088207C187882448 @default.
• W2002088207 hasConceptScore W2002088207C189482833 @default.
• W2002088207 hasConceptScore W2002088207C196436469 @default.
• W2002088207 hasConceptScore W2002088207C2909221355 @default.
• W2002088207 hasConceptScore W2002088207C36823959 @default.
• W2002088207 hasConceptScore W2002088207C47289529 @default.
• W2002088207 hasConceptScore W2002088207C54355233 @default.
• W2002088207 hasConceptScore W2002088207C86803240 @default.
• W2002088207 hasConceptScore W2002088207C94671646 @default.
• W2002088207 hasConceptScore W2002088207C95444343 @default.
• W2002088207 hasIssue "2" @default.
• W2002088207 hasLocation W20020882071 @default.
• W2002088207 hasLocation W20020882072 @default.
• W2002088207 hasOpenAccess W2002088207 @default.
• W2002088207 hasPrimaryLocation W20020882071 @default.
• W2002088207 hasRelatedWork W1915414624 @default.
• W2002088207 hasRelatedWork W2004344796 @default.
• W2002088207 hasRelatedWork W2009810944 @default.
• W2002088207 hasRelatedWork W2065739243 @default.
• W2002088207 hasRelatedWork W2068048912 @default.
• W2002088207 hasRelatedWork W2074111310 @default.
• W2002088207 hasRelatedWork W2122891560 @default.
• W2002088207 hasRelatedWork W2364819952 @default.
• W2002088207 hasRelatedWork W2365974448 @default.
• W2002088207 hasRelatedWork W2382593249 @default.
• W2002088207 hasVolume "70" @default.
• W2002088207 isParatext "false" @default.
• W2002088207 isRetracted "false" @default.
• W2002088207 magId "2002088207" @default.
• W2002088207 workType "article" @default.