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• W2002089999 abstract "Magnetically aligned bicelles are increasingly being used as model membranes in solution- and solid-state NMR studies of the structure, dynamics, topology, and interaction of membrane-associated peptides and proteins. These studies commonly utilize the PISEMA pulse sequence to measure dipolar coupling and chemical shift, the two key parameters used in subsequent structural analysis. In the present study, we demonstrate that the PISEMA and other rotating-frame pulse sequences are not suitable for the measurement of long-range heteronuclear dipolar couplings, and that they provide inaccurate values when multiple protons are coupled to a 13C nucleus. Furthermore, we demonstrate that a laboratory-frame separated-local-field experiment is capable of overcoming these difficulties in magnetically aligned bicelles. An extension of this approach to accurately measure 13C−31P and 1H−31P couplings from phospholipids, which are useful to understand the interaction of molecules with the membrane, is also described. In these 2D experiments, natural abundance 13C was observed from bicelles containing DMPC and DHPC lipid molecules. As a first application, these solid-state NMR approaches were utilized to probe the membrane interaction of an antidepressant molecule, desipramine, and its location in the membrane." @default.
• W2002089999 created "2016-06-24" @default.
• W2002089999 creator A5006414766 @default.
• W2002089999 creator A5010392700 @default.
• W2002089999 creator A5067034646 @default.
• W2002089999 creator A5073092990 @default.
• W2002089999 date "2007-01-01" @default.
• W2002089999 modified "2023-09-27" @default.
• W2002089999 title "High-Resolution 2D NMR Spectroscopy of Bicelles To Measure the Membrane Interaction of Ligands" @default.
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• W2002089999 doi "https://doi.org/10.1021/ja065536k" @default.
• W2002089999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2527737" @default.
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