FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002091294> ?p ?o ?g. }

• W2002091294 endingPage "405" @default.
• W2002091294 startingPage "395" @default.
• W2002091294 abstract "Scyliorhinin II, a cyclic Tachykinin peptide, is a potent NK3 receptor agonist. The pharmacology of NK3 receptor is least characterized out of the three tachykinin receptor subtypes cloned and characterized for Tachykinins. To understand the structural basis of peptide-receptor interaction, the three-dimensional structure of the Scyliorhinin II in aqueous and micellar environments has been studied by two-dimensional proton nuclear magnetic resonance (2D 1H-NMR spectroscopy) and distance geometry calculations. Proton NMR assignments have been carried out with the aid of correlation spectroscopy (gradient-COSY and TOCSY) and nuclear Overhauser effect spectroscopy (NOESY and ROESY) experiments. The inter proton distances and dihedral angle constraints obtained from the NMR data have been used in torsion angle dynamics algorithm for NMR applications (DYANA) to generate a family of structures, which have been refined using restrained energy minimization and dynamics. The results show that in an aqueous environment, Scyliorhinin II lacks a definite secondary structure. The structure is well-defined in presence of dodecyl phosphocholine micelles. The global fold of Scyliorhinin II bound to DPC micelles consists of a well-defined helix in the C-terminal region from residue 12-18 and a series of turns towards N-terminus. The structure is further stabilized by disulfide bond between Cys7 and Cys13. The conformational range of the peptide revealed by NMR and CD studies has been analyzed in terms of characteristic secondary features. Observed conformational features have been compared with those of Substance P, Neurokinin A and Neurokinin B, potent NK1, NK2, and NK3 agonists, respectively." @default.
• W2002091294 created "2016-06-24" @default.
• W2002091294 creator A5029100778 @default.
• W2002091294 creator A5052616642 @default.
• W2002091294 date "2008-02-01" @default.
• W2002091294 modified "2023-09-26" @default.
• W2002091294 title "Structural Characterization of Neurokinin-3 Receptor Selective Peptide Agonist Scyliorhinin II Bound to DPC Micelles" @default.
• W2002091294 cites W1545622372 @default.
• W2002091294 cites W1968246808 @default.
• W2002091294 cites W1971813416 @default.
• W2002091294 cites W1976274800 @default.
• W2002091294 cites W1979032136 @default.
• W2002091294 cites W1986191025 @default.
• W2002091294 cites W1986396635 @default.
• W2002091294 cites W1987112862 @default.
• W2002091294 cites W1993049870 @default.
• W2002091294 cites W1994820130 @default.
• W2002091294 cites W1996357463 @default.
• W2002091294 cites W1997067647 @default.
• W2002091294 cites W1997354900 @default.
• W2002091294 cites W1997386092 @default.
• W2002091294 cites W1998507169 @default.
• W2002091294 cites W2002526993 @default.
• W2002091294 cites W2006925909 @default.
• W2002091294 cites W2007880939 @default.
• W2002091294 cites W2011626323 @default.
• W2002091294 cites W2014299150 @default.
• W2002091294 cites W2016470280 @default.
• W2002091294 cites W2023465278 @default.
• W2002091294 cites W2028488559 @default.
• W2002091294 cites W2029166770 @default.
• W2002091294 cites W2038304285 @default.
• W2002091294 cites W2040186907 @default.
• W2002091294 cites W2043332332 @default.
• W2002091294 cites W2044846931 @default.
• W2002091294 cites W2052933818 @default.
• W2002091294 cites W2067864338 @default.
• W2002091294 cites W2071249477 @default.
• W2002091294 cites W2076771427 @default.
• W2002091294 cites W2079564988 @default.
• W2002091294 cites W2081801618 @default.
• W2002091294 cites W2082993709 @default.
• W2002091294 cites W2085265931 @default.
• W2002091294 cites W2085698021 @default.
• W2002091294 cites W2088313656 @default.
• W2002091294 cites W2088848851 @default.
• W2002091294 cites W2089167230 @default.
• W2002091294 cites W2094604448 @default.
• W2002091294 cites W2103692741 @default.
• W2002091294 cites W2134057677 @default.
• W2002091294 cites W2151596590 @default.
• W2002091294 cites W2159348568 @default.
• W2002091294 cites W2159423221 @default.
• W2002091294 cites W2168715118 @default.
• W2002091294 cites W2172093339 @default.
• W2002091294 cites W2279098020 @default.
• W2002091294 cites W2334261900 @default.
• W2002091294 doi "https://doi.org/10.1080/07391102.2008.10507188" @default.
• W2002091294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18092834" @default.
• W2002091294 hasPublicationYear "2008" @default.
• W2002091294 type Work @default.
• W2002091294 sameAs 2002091294 @default.
• W2002091294 citedByCount "0" @default.
• W2002091294 crossrefType "journal-article" @default.
• W2002091294 hasAuthorship W2002091294A5029100778 @default.
• W2002091294 hasAuthorship W2002091294A5052616642 @default.
• W2002091294 hasConcept C103319777 @default.
• W2002091294 hasConcept C11268172 @default.
• W2002091294 hasConcept C112887158 @default.
• W2002091294 hasConcept C119851462 @default.
• W2002091294 hasConcept C170493617 @default.
• W2002091294 hasConcept C178790620 @default.
• W2002091294 hasConcept C184651966 @default.
• W2002091294 hasConcept C185592680 @default.
• W2002091294 hasConcept C19549132 @default.
• W2002091294 hasConcept C2778938600 @default.
• W2002091294 hasConcept C2779281246 @default.
• W2002091294 hasConcept C32909587 @default.
• W2002091294 hasConcept C55493867 @default.
• W2002091294 hasConcept C66974803 @default.
• W2002091294 hasConcept C71240020 @default.
• W2002091294 hasConcept C8010536 @default.
• W2002091294 hasConcept C89025888 @default.
• W2002091294 hasConceptScore W2002091294C103319777 @default.
• W2002091294 hasConceptScore W2002091294C11268172 @default.
• W2002091294 hasConceptScore W2002091294C112887158 @default.
• W2002091294 hasConceptScore W2002091294C119851462 @default.
• W2002091294 hasConceptScore W2002091294C170493617 @default.
• W2002091294 hasConceptScore W2002091294C178790620 @default.
• W2002091294 hasConceptScore W2002091294C184651966 @default.
• W2002091294 hasConceptScore W2002091294C185592680 @default.
• W2002091294 hasConceptScore W2002091294C19549132 @default.
• W2002091294 hasConceptScore W2002091294C2778938600 @default.
• W2002091294 hasConceptScore W2002091294C2779281246 @default.
• W2002091294 hasConceptScore W2002091294C32909587 @default.
• W2002091294 hasConceptScore W2002091294C55493867 @default.
• W2002091294 hasConceptScore W2002091294C66974803 @default.
• W2002091294 hasConceptScore W2002091294C71240020 @default.

• next