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• W2002092114 abstract "The QSAR studies of 5-substituted-2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles set of antiproliferative activity against human cancer cell lines have been performed. Electronic properties of compounds were estimated by the Hartree-Fock method at 6-31G** level. Lipophilicity and membrane affinity parameters were determined by the chromatographic methods RP-8 OPLC and IAM HPLC, respectively. Mono- and multivariable regression analyses were performed. The principle factor for determination of activity of compounds is partial charge of nitrogen (q(N3), q(N4)) and carbon (q(C5)) atoms of the 1,3,4-thiadiazole ring. Biological effect is also connected with molar refractivity (CMR) and lipophilicity of derivatives obtained by RP-8 chromatography. The analysis of the QSAR equations for individual cell lines indicates both similarities and differences of electron, steric factors and hydrophobic-hydrophilic character of the analogues of the tested set affecting the antiproliferative activity." @default.
• W2002092114 created "2016-06-24" @default.
• W2002092114 creator A5082641894 @default.
• W2002092114 date "2007-07-01" @default.
• W2002092114 modified "2023-10-03" @default.
• W2002092114 title "Evaluation of electronic, lipophilic and membrane affinity effects on antiproliferative activity of 5-substituted-2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles against various human cancer cells" @default.
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• W2002092114 doi "https://doi.org/10.1016/j.ejmech.2006.12.033" @default.
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