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• W2002092803 abstract "Interleukin 31 (IL-31) is a T helper type 2 effector cytokine that plays an important role in the pathogenesis of atopic and allergic diseases. IL-31 may be involved in promoting allergic inflammation and in inducing airway epithelial responses such as allergic asthma.Single-base extension analysis was used to detect the genotypes of IL-31 single nucleotide polymorphisms (SNPs), and we compared the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls.There were no significant differences in the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls. Furthermore we compared the genotype and allele frequencies of IL-31 SNPs between patients with atopic asthma, those with non-atopic asthma and healthy controls. This showed that the SNPs were not associated with the susceptibility to atopic asthma. There were no significant differences in the haplotype frequencies of IL-31 SNPs between patients with asthma and healthy controls. In patients with asthma, the IL-31 SNPs were significantly correlated with total serum levels of IgE (p=0.035).Our results indicate that, the IL-31 SNPs may be associated with IgE production in patients with asthma." @default.
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• W2002092803 date "2012-01-01" @default.
• W2002092803 modified "2023-10-18" @default.
• W2002092803 title "Identifying Polymorphisms in<i>IL-31</i>and Their Association with Susceptibility to Asthma" @default.
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• W2002092803 doi "https://doi.org/10.4132/koreanjpathol.2012.46.2.162" @default.
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