FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002095409> ?p ?o ?g. }

• W2002095409 endingPage "126" @default.
• W2002095409 startingPage "119" @default.
• W2002095409 abstract "Objective: Given the large phenotypic diversity of asthma, our aim was to characterize molecular profiles related to asthma severity using selected remodeling biomarkers in induced sputum. Methods: Induced sputum from healthy controls, patients with mild to moderate asthma and severe asthma were collected. Twelve selected biomarkers previously associated to airway remodeling such as connective tissue growth factor (CTGF), fibroblast growth factor (FGF)-2, matrix metalloproteinase (MMP)-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, procollagen type 1 and tissue inhibitor of metalloproteinase (TIMP)-1 were measured in sputum samples using ELISA or Luminex technology. FGF-2 level was also evaluated in bronchial biopsies using immunohistochemistry. Results: Sputum of severe asthma was characterized by reduced percentage of macrophages and increased percentage of neutrophils and eosinophils. FGF-2, MMP-1 and TIMP-1 levels increased with asthma severity. Interestingly, only FGF-2 level inversely correlated with FEV1/FVC ratio. Although percentage of eosinophils correlated with asthma severity, it did not correlate with FGF-2 levels. Increased levels of FGF-2 with asthma severity were confirmed in bronchial biopsies by immunohistochemistry. Conclusions: Level of FGF-2 in induced sputum represents a relevant remodeling biomarker of asthma severity and significantly correlates with pulmonary function. FGF-2 sputum biomarker is proposed to reveal the phenotype of asthma characterized by fixed airflow obstruction." @default.
• W2002095409 created "2016-06-24" @default.
• W2002095409 creator A5000657922 @default.
• W2002095409 creator A5012262499 @default.
• W2002095409 creator A5027127170 @default.
• W2002095409 creator A5057871020 @default.
• W2002095409 creator A5065588213 @default.
• W2002095409 creator A5069408014 @default.
• W2002095409 creator A5084946954 @default.
• W2002095409 creator A5087705837 @default.
• W2002095409 creator A5090752391 @default.
• W2002095409 date "2013-11-25" @default.
• W2002095409 modified "2023-10-03" @default.
• W2002095409 title "Fibroblast growth factor-2 is a sputum remodeling biomarker of severe asthma" @default.
• W2002095409 cites W1965751894 @default.
• W2002095409 cites W1966306124 @default.
• W2002095409 cites W1966493836 @default.
• W2002095409 cites W1975696541 @default.
• W2002095409 cites W1976434950 @default.
• W2002095409 cites W1998424851 @default.
• W2002095409 cites W1999039702 @default.
• W2002095409 cites W2001643672 @default.
• W2002095409 cites W2010011258 @default.
• W2002095409 cites W2013105339 @default.
• W2002095409 cites W2023520614 @default.
• W2002095409 cites W2030389672 @default.
• W2002095409 cites W2030728967 @default.
• W2002095409 cites W2040099837 @default.
• W2002095409 cites W2042575137 @default.
• W2002095409 cites W2049865769 @default.
• W2002095409 cites W2053664189 @default.
• W2002095409 cites W2068881594 @default.
• W2002095409 cites W2085600133 @default.
• W2002095409 cites W2086283601 @default.
• W2002095409 cites W2091453177 @default.
• W2002095409 cites W2096759470 @default.
• W2002095409 cites W2099543104 @default.
• W2002095409 cites W2103109767 @default.
• W2002095409 cites W2109781176 @default.
• W2002095409 cites W2112989452 @default.
• W2002095409 cites W2118025157 @default.
• W2002095409 cites W2125252801 @default.
• W2002095409 cites W2131024302 @default.
• W2002095409 cites W2145153937 @default.
• W2002095409 cites W2154395313 @default.
• W2002095409 cites W2155650191 @default.
• W2002095409 cites W2160053403 @default.
• W2002095409 doi "https://doi.org/10.3109/02770903.2013.860164" @default.
• W2002095409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24188024" @default.
• W2002095409 hasPublicationYear "2013" @default.
• W2002095409 type Work @default.
• W2002095409 sameAs 2002095409 @default.
• W2002095409 citedByCount "26" @default.
• W2002095409 countsByYear W20020954092014 @default.
• W2002095409 countsByYear W20020954092015 @default.
• W2002095409 countsByYear W20020954092016 @default.
• W2002095409 countsByYear W20020954092018 @default.
• W2002095409 countsByYear W20020954092019 @default.
• W2002095409 countsByYear W20020954092020 @default.
• W2002095409 countsByYear W20020954092021 @default.
• W2002095409 countsByYear W20020954092022 @default.
• W2002095409 countsByYear W20020954092023 @default.
• W2002095409 crossrefType "journal-article" @default.
• W2002095409 hasAuthorship W2002095409A5000657922 @default.
• W2002095409 hasAuthorship W2002095409A5012262499 @default.
• W2002095409 hasAuthorship W2002095409A5027127170 @default.
• W2002095409 hasAuthorship W2002095409A5057871020 @default.
• W2002095409 hasAuthorship W2002095409A5065588213 @default.
• W2002095409 hasAuthorship W2002095409A5069408014 @default.
• W2002095409 hasAuthorship W2002095409A5084946954 @default.
• W2002095409 hasAuthorship W2002095409A5087705837 @default.
• W2002095409 hasAuthorship W2002095409A5090752391 @default.
• W2002095409 hasConcept C126322002 @default.
• W2002095409 hasConcept C142724271 @default.
• W2002095409 hasConcept C170493617 @default.
• W2002095409 hasConcept C189165786 @default.
• W2002095409 hasConcept C203014093 @default.
• W2002095409 hasConcept C2775960820 @default.
• W2002095409 hasConcept C2776042228 @default.
• W2002095409 hasConcept C2776301714 @default.
• W2002095409 hasConcept C2777699602 @default.
• W2002095409 hasConcept C2780631158 @default.
• W2002095409 hasConcept C2781069245 @default.
• W2002095409 hasConcept C2781197716 @default.
• W2002095409 hasConcept C55493867 @default.
• W2002095409 hasConcept C71924100 @default.
• W2002095409 hasConcept C86803240 @default.
• W2002095409 hasConcept C95444343 @default.
• W2002095409 hasConceptScore W2002095409C126322002 @default.
• W2002095409 hasConceptScore W2002095409C142724271 @default.
• W2002095409 hasConceptScore W2002095409C170493617 @default.
• W2002095409 hasConceptScore W2002095409C189165786 @default.
• W2002095409 hasConceptScore W2002095409C203014093 @default.
• W2002095409 hasConceptScore W2002095409C2775960820 @default.
• W2002095409 hasConceptScore W2002095409C2776042228 @default.
• W2002095409 hasConceptScore W2002095409C2776301714 @default.
• W2002095409 hasConceptScore W2002095409C2777699602 @default.
• W2002095409 hasConceptScore W2002095409C2780631158 @default.

• next