FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002096619> ?p ?o ?g. }

• W2002096619 endingPage "516" @default.
• W2002096619 startingPage "505" @default.
• W2002096619 abstract "Ischemic brain stroke is a leading cause of disability and includes hearing loss. Clinical reports have also suggested that there is hearing loss in stroke patients but the mechanism was not determined. Therefore, we hypothesized that hearing loss after cerebral ischemia may be associated with changes to the synapse, gap junction, and sodium channel (NaC) proteins. Ischemia-reperfusion injury was induced in wild-type mice (I/R group). The lesion volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining of the brain sections. BBB disruption was confirmed by Evans blue staining and leakage of bovine serum albumin labeled with fluorescein isothiocyanate (BSA-FITC). We found that brain edema, infarct size, and permeability were increased in ischemic mice as compared with the sham-operated group. Caspase-3, caspase-9, and TUNEL-positive cells were increased in I/R mice, indicating neuronal apoptosis. Moreover, there were increased expressions of matrix metalloprotease's (MMP-2, -3, -9, and -13), interleukin (IL)-6, and decreased expressions of tight junction proteins (TJP) in the I/R group, as compared with the sham group, which signifies inflammation and BBB disruption. We also observed decreased levels of post-synaptic density protein-95 (PSD-95), synapse-associated protein 97 (SAP-97), connexin-43, NaC-α, and NaC-β, and increased expression of connexin-45, whereas no substantial change was observed in connexin-26 expression in the I/R group. Interestingly, auditory response was reduced in the I/R mice, indicating hearing loss. These data suggest that hearing loss in ischemic mice was primarily due to alterations in connexin, synapses, and NaC channels." @default.
• W2002096619 created "2016-06-24" @default.
• W2002096619 creator A5003454740 @default.
• W2002096619 creator A5026058313 @default.
• W2002096619 creator A5029264358 @default.
• W2002096619 creator A5044988082 @default.
• W2002096619 creator A5051938836 @default.
• W2002096619 date "2015-07-01" @default.
• W2002096619 modified "2023-10-16" @default.
• W2002096619 title "A possible molecular mechanism of hearing loss during cerebral ischemia in mice" @default.
• W2002096619 cites W128151115 @default.
• W2002096619 cites W1537453000 @default.
• W2002096619 cites W1820962178 @default.
• W2002096619 cites W1965818446 @default.
• W2002096619 cites W1971486820 @default.
• W2002096619 cites W1977509730 @default.
• W2002096619 cites W1987288646 @default.
• W2002096619 cites W1999473120 @default.
• W2002096619 cites W2005875293 @default.
• W2002096619 cites W2022970771 @default.
• W2002096619 cites W2023749167 @default.
• W2002096619 cites W2025105684 @default.
• W2002096619 cites W2028037111 @default.
• W2002096619 cites W2030661862 @default.
• W2002096619 cites W2039015646 @default.
• W2002096619 cites W2039176792 @default.
• W2002096619 cites W2042623096 @default.
• W2002096619 cites W2042752773 @default.
• W2002096619 cites W2043191266 @default.
• W2002096619 cites W2052060592 @default.
• W2002096619 cites W2052322755 @default.
• W2002096619 cites W2053943918 @default.
• W2002096619 cites W2056709999 @default.
• W2002096619 cites W2057291185 @default.
• W2002096619 cites W2060298694 @default.
• W2002096619 cites W2060560910 @default.
• W2002096619 cites W2071190017 @default.
• W2002096619 cites W2073923875 @default.
• W2002096619 cites W2100888378 @default.
• W2002096619 cites W2102146294 @default.
• W2002096619 cites W2103278596 @default.
• W2002096619 cites W2109015013 @default.
• W2002096619 cites W2112505121 @default.
• W2002096619 cites W2113892795 @default.
• W2002096619 cites W2115434419 @default.
• W2002096619 cites W2117024164 @default.
• W2002096619 cites W2121979986 @default.
• W2002096619 cites W2129247391 @default.
• W2002096619 cites W2135368782 @default.
• W2002096619 cites W2139592709 @default.
• W2002096619 cites W2144326284 @default.
• W2002096619 cites W2147915412 @default.
• W2002096619 cites W2148987235 @default.
• W2002096619 cites W2148992136 @default.
• W2002096619 cites W2156406678 @default.
• W2002096619 cites W2162189519 @default.
• W2002096619 cites W2167956961 @default.
• W2002096619 cites W2170159267 @default.
• W2002096619 cites W293749553 @default.
• W2002096619 cites W1990701478 @default.
• W2002096619 doi "https://doi.org/10.1139/cjpp-2014-0489" @default.
• W2002096619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4567529" @default.
• W2002096619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26034997" @default.
• W2002096619 hasPublicationYear "2015" @default.
• W2002096619 type Work @default.
• W2002096619 sameAs 2002096619 @default.
• W2002096619 citedByCount "11" @default.
• W2002096619 countsByYear W20020966192015 @default.
• W2002096619 countsByYear W20020966192018 @default.
• W2002096619 countsByYear W20020966192019 @default.
• W2002096619 countsByYear W20020966192020 @default.
• W2002096619 countsByYear W20020966192022 @default.
• W2002096619 countsByYear W20020966192023 @default.
• W2002096619 crossrefType "journal-article" @default.
• W2002096619 hasAuthorship W2002096619A5003454740 @default.
• W2002096619 hasAuthorship W2002096619A5026058313 @default.
• W2002096619 hasAuthorship W2002096619A5029264358 @default.
• W2002096619 hasAuthorship W2002096619A5044988082 @default.
• W2002096619 hasAuthorship W2002096619A5051938836 @default.
• W2002096619 hasBestOaLocation W20020966192 @default.
• W2002096619 hasConcept C105702510 @default.
• W2002096619 hasConcept C121332964 @default.
• W2002096619 hasConcept C126322002 @default.
• W2002096619 hasConcept C134018914 @default.
• W2002096619 hasConcept C158157758 @default.
• W2002096619 hasConcept C177779419 @default.
• W2002096619 hasConcept C196795494 @default.
• W2002096619 hasConcept C204232928 @default.
• W2002096619 hasConcept C2775962179 @default.
• W2002096619 hasConcept C2776914184 @default.
• W2002096619 hasConcept C2777019933 @default.
• W2002096619 hasConcept C2777649898 @default.
• W2002096619 hasConcept C2778402981 @default.
• W2002096619 hasConcept C2778500370 @default.
• W2002096619 hasConcept C2780228694 @default.
• W2002096619 hasConcept C2780921233 @default.
• W2002096619 hasConcept C529278444 @default.
• W2002096619 hasConcept C541997718 @default.

• next