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- W2002097029 abstract "Summary We have developed a simple thermodynamic model to represent the entire binding isotherm for cooperative binding systems such as the triple helix formed by adenosine and polyuridylic acid (poly-U). An equation is derived to express θ (the fraction of poly-U sites occupied by bound molecules) as a function of C a (the concentration of free adenosine) and two parameters, K 1 and n. K 1 is related to the total free energy of binding of a monomer unit in the complex and n is the minimum number of monomer units which must interact cooperatively with the polymer to form a stable complex. Accurate values of both C a and dθ/dC a at θ=½ can be calculated from the analytical expression for θ(C a ). For a sample of unmodified poly-U we found that K 1 = 432M −1 and n = 5 were the optimum values of the parameters. The mathematical form of the binding isotherm and computational procedures also apply to binding data for adenosine on modified poly-U." @default.
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- W2002097029 date "1974-01-01" @default.
- W2002097029 modified "2023-09-24" @default.
- W2002097029 title "A model for the binding of adenosine to polyuridylic acid" @default.
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- W2002097029 doi "https://doi.org/10.1016/s0006-291x(74)80310-4" @default.
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