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• W2002102389 abstract "Abstract The effect of early reperfusion after intracoronary infusion of streptokinase in patients with acute myocardial infarction was assessed in 27 patients by serial analysis of serum creatine kinase (CK) activity, thallium-201 scintigraphy (seven pinhole technique) and left ventricular and coronary angiography. Serial serum CK activity determinations were carried out at hourly intervals. Thallium-201 tomographic scintigrams were obtained before and 24 hours after recanalization. The size of the perfusion defect was measured from eight scintigraphic cross sections of the left ventricle. Regional ejection fraction was determined from the left ventricular angiogram before and 4 weeks after recanalization. The results in three groups of patients are presented: group A, 10 patients with successful recanalization and a peak serum CK activity of less than 1,000 U/liter; group B, 9 patients with successful recanalization and a peak serum CK activity of more than 1,000 U/liter and group C, 8 patients with unsuccessful recanalization. Patients in group A showed an increase in CK activity (from 46 to 603 U/liter p p p p p p > 0.05). Patients in group C had an increase in serum CK activity (from 43 to 1,756 U/liter, p p > 0.05) and no change in regional ejection fraction (from 32 to 26 percent, p >0.05). Compared with patients in group B, those in group A had a shorter duration of ischemia (3.9 versus 4.8 hours), more frequently adequate collateral supply to the infarcting area before recanalization (40 versus 0 percent of patients) and a smaller area supplied by the occluded vessel (115 versus 141 °). Although all differences were not at the level of significance ( p > 0.05), conditions for tolerating ischemia were better in group A than in group B. The study shows that early reperfusion has a beneficial effect on the extent of myocardial necrosis as estimated from serum enzyme determinations, thallium-201 scintigraphy and contrast ventriculography. The beneficial effect depends on the duration of myocardial ischemia and on the blood supply to the ischemic area by collateral vessels." @default.
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• W2002102389 date "1982-07-01" @default.
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• W2002102389 title "Intracoronary thrombolysis in acute myocardial infarction: Correlations among serum enzyme, scintigraphic and hemodynamic findings" @default.
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• W2002102389 doi "https://doi.org/10.1016/0002-9149(82)90005-4" @default.
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