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- W2002102821 abstract "BQ-123 (cyclo[D-Trp-D-Asp-Pro-D-Val-Leu]) is a competitive antagonist of the ETA receptor subtype for endothelins in aortic myocytes, and a non-competitive antagonist in human neuroblastoma cells. In the present study, using indo-1 loaded rat brain capillary endothelial cells, we demonstrate that BQ-123 acts either as a non-competitive antagonist of endothelin-1 action on [Ca2+]i depending on the experimental conditions used. A simple hypothesis to account for these results is that BQ-123 forms stable complexes with ETA receptors that are, however, less stable than the complexes formed by endothelin-1 and ETA receptors." @default.
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- W2002102821 date "1993-05-01" @default.
- W2002102821 modified "2023-09-25" @default.
- W2002102821 title "Competitive and non competitive interactions of BQ-123 with endothelin ETA receptors" @default.
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- W2002102821 doi "https://doi.org/10.1016/0922-4106(93)90101-e" @default.
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