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- W2002102829 abstract "Whether or not functionalized PEGs may be useful in the case of low molecular weight drugs has not yet been examined so far. For that purpose captopril, a thiol containing drug, was converted into a prodrug, captopril-S-S-PEG, which does not inhibit ACE activity. The inhibitory action of captopril-SH can be regenerated by chemical reduction (gluthatione, DTT or NaBH4) of that prodrug. Yet, as those chemical reagents themselves partially inhibit ACE activity, the inhibitory effect of the freed captopril-SH alone was shown to be fully recovered after coulometric reduction." @default.
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- W2002102829 date "1996-05-28" @default.
- W2002102829 modified "2023-09-25" @default.
- W2002102829 title "Poly(ethylene glycol) derivatized prodrugs through mixed disulfide bond formation: Preliminary report on captopril" @default.
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- W2002102829 doi "https://doi.org/10.1016/0378-5173(95)04405-1" @default.
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