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- W2002105288 abstract "Introduction Biological characterization of mesenchymal stem cells Aetiology and current treatment of type 1 diabetes Mesenchymal stem cells in type 1 diabetes therapy Concluding remarks Abstract Mesenchymal stem cells (MSCs) can be derived from adult bone marrow, fat and several foetal tissues. In vitro , MSCs have the capacity to differentiate into multiple mesodermal and non‐mesodermal cell lineages. Besides, MSCs possess immunosuppressive effects by modulating the immune function of the major cell populations involved in alloantigen recognition and elimination. The intriguing biology of MSCs makes them strong candidates for cell‐based therapy against various human diseases. Type 1 diabetes is caused by a cell‐mediated autoimmune destruction of pancreatic β‐cells. While insulin replacement remains the cornerstone treatment for type 1 diabetes, the transplantation of pancreatic islets of Langerhans provides a cure for this disorder. And yet, islet transplantation is limited by the lack of donor pancreas. Generation of insulin‐producing cells (IPCs) from MSCs represents an attractive alternative. On the one hand, MSCs from pancreas, bone marrow, adipose tissue, umbilical cord blood and cord tissue have the potential to differentiate into IPCs by genetic modification and/or defined culture conditions In vitro . On the other hand, MSCs are able to serve as a cellular vehicle for the expression of human insulin gene. Moreover, protein transduction technology could offer a novel approach for generating IPCs from stem cells including MSCs. In this review, we first summarize the current knowledge on the biological characterization of MSCs. Next, we consider MSCs as surrogate β‐cell source for islet transplantation, and present some basic requirements for these replacement cells. Finally, MSCs‐mediated therapeutic neovascularization in type 1 diabetes is discussed." @default.
- W2002105288 created "2016-06-24" @default.
- W2002105288 creator A5032405701 @default.
- W2002105288 creator A5087592842 @default.
- W2002105288 date "2008-08-01" @default.
- W2002105288 modified "2023-10-16" @default.
- W2002105288 title "Mesenchymal stem cells: biology and clinical potential in type 1 diabetes therapy" @default.
- W2002105288 cites W125090202 @default.
- W2002105288 cites W1518831632 @default.
- W2002105288 cites W153768115 @default.
- W2002105288 cites W1555330200 @default.
- W2002105288 cites W1602657004 @default.
- W2002105288 cites W1718946616 @default.
- W2002105288 cites W181843795 @default.
- W2002105288 cites W1844685923 @default.
- W2002105288 cites W1963528166 @default.
- W2002105288 cites W1966413790 @default.
- W2002105288 cites W1967077194 @default.
- W2002105288 cites W1968145681 @default.
- W2002105288 cites W1969281312 @default.
- W2002105288 cites W1970007383 @default.
- W2002105288 cites W1970590929 @default.
- W2002105288 cites W1973866953 @default.
- W2002105288 cites W1974207011 @default.
- W2002105288 cites W1976221714 @default.
- W2002105288 cites W1981708789 @default.
- W2002105288 cites W1982022033 @default.
- W2002105288 cites W1982408656 @default.
- W2002105288 cites W1982990627 @default.
- W2002105288 cites W1983259364 @default.
- W2002105288 cites W1986300999 @default.
- W2002105288 cites W1986457784 @default.
- W2002105288 cites W1986576634 @default.
- W2002105288 cites W1988519907 @default.
- W2002105288 cites W1991141405 @default.
- W2002105288 cites W1991248271 @default.
- W2002105288 cites W1991493548 @default.
- W2002105288 cites W1993514403 @default.
- W2002105288 cites W1993902386 @default.
- W2002105288 cites W1994586809 @default.
- W2002105288 cites W1995937915 @default.
- W2002105288 cites W1996773781 @default.
- W2002105288 cites W1996789930 @default.
- W2002105288 cites W1997470313 @default.
- W2002105288 cites W2004247546 @default.
- W2002105288 cites W2005186082 @default.
- W2002105288 cites W2005325445 @default.
- W2002105288 cites W2005848913 @default.
- W2002105288 cites W2006179587 @default.
- W2002105288 cites W2006601515 @default.
- W2002105288 cites W2007421494 @default.
- W2002105288 cites W2007452027 @default.
- W2002105288 cites W2008028335 @default.
- W2002105288 cites W2011653132 @default.
- W2002105288 cites W2012222854 @default.
- W2002105288 cites W2013568009 @default.
- W2002105288 cites W2013621644 @default.
- W2002105288 cites W2014673628 @default.
- W2002105288 cites W2017496728 @default.
- W2002105288 cites W2019495971 @default.
- W2002105288 cites W2022248346 @default.
- W2002105288 cites W2023842938 @default.
- W2002105288 cites W2024971445 @default.
- W2002105288 cites W2028174844 @default.
- W2002105288 cites W2028212562 @default.
- W2002105288 cites W2028239901 @default.
- W2002105288 cites W2030920153 @default.
- W2002105288 cites W2031812736 @default.
- W2002105288 cites W2032032556 @default.
- W2002105288 cites W2032181767 @default.
- W2002105288 cites W2033514910 @default.
- W2002105288 cites W2034390132 @default.
- W2002105288 cites W2035176325 @default.
- W2002105288 cites W2035582618 @default.
- W2002105288 cites W2035976926 @default.
- W2002105288 cites W2036390713 @default.
- W2002105288 cites W2037085194 @default.
- W2002105288 cites W2038467210 @default.
- W2002105288 cites W2039665103 @default.
- W2002105288 cites W2040426333 @default.
- W2002105288 cites W2044695442 @default.
- W2002105288 cites W2044829718 @default.
- W2002105288 cites W2047003816 @default.
- W2002105288 cites W2047063964 @default.
- W2002105288 cites W2047754799 @default.
- W2002105288 cites W2052634826 @default.
- W2002105288 cites W2052721366 @default.
- W2002105288 cites W2054095354 @default.
- W2002105288 cites W2054274983 @default.
- W2002105288 cites W2054507508 @default.
- W2002105288 cites W2060619977 @default.
- W2002105288 cites W2060725998 @default.
- W2002105288 cites W2061208107 @default.
- W2002105288 cites W2062915300 @default.
- W2002105288 cites W2064919073 @default.
- W2002105288 cites W2066793359 @default.
- W2002105288 cites W2073767301 @default.
- W2002105288 cites W2075647222 @default.