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• W2002108164 abstract "1. The inactivation of the T7 coliphage by ethyl methanesulfonate, whether tested immediately after the treatment or after a variable delay, is a one-hit process. Delayed inactivation is due exclusively to depurination: one lethal hit corresponds to seven or eight depurinations per phage. In contrast, depurination cannot explain all the inactivation at the end of the treatment. 2. The lethality of the T7 coliphage treated by nitrogen mustard first increases after the end of a 30-min treatment, passes through a maximum 90 min later, decreases and passes through a minimum after 2 days to increase again afterwards. The inactivation is a single-hit process at any time during this evolution. DNA interstrand crosslinks are the only cause of lethality at the end of the treatment and for several hours later. The increase and the following decrease of lethality are due to the formation of crosslinks and their subsequent disappearance. After 3 days, the crosslinks have disappeared and the bifunctional alkylating agent does not seem more toxic than a monofunctional one; depurination might be the only cause of the late lethality. 3. Myleran behaves as a monofunctional alkylating agent in the inactivation of the T7 coliphage. Its mode of action is very similar to that of ethyl methanesulfonate (half-myleran): the lethality increases steadily after the end of the treatment; no interstrand DNA crosslinks can be found." @default.
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• W2002108164 date "1970-08-01" @default.
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• W2002108164 title "The lethal action of ethyl methanesulfonate, nitrogen mustard and myleran on the T7 coliphage" @default.
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• W2002108164 doi "https://doi.org/10.1016/0005-2787(70)90038-9" @default.
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