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• W2002109566 abstract "Introduction: Experience with the use of allogeneic hemopoietic stem transplantation (AHSCT) in pediatric myelodisplastic syndrome (MDS) in Spain is reviewed. Methods and patients: Twenty-four children with MDS were analyzed retrospectively. Median age of the patients was 10 years. Twenty patients received a bone marrow graft and 4 an unrelated cord blood (UCB) transplant; 12 bone marrow grafts were from a matched related donor (MRD) and 8 from a matched unrelated donor (MUD). Conditioning regimen consisted of chemotherapy alone in 17 patients (busulfan and cyclophosphamide ± melfalan) Seven patients received TBI and cyclophosphamide. Results: Ten patients died from transplant-related toxicity and 4 had relapse or disease progression post-AHSCT. Nine patients are alive and event-free with a median follow-up of 120 months. EFS rate in the MRD group was 0.48 (SE 0.13) versus 0.25 (SE 0.12) in the MUD/UCB group (p =. 07). Lansky score in survivors is ≥90%. Conclusions: In this historical series of children with MDS, in spite of severe transplant–related toxicity, encouraging EFS outcomes have been achieved after AHSCT with good quality of life." @default.
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• W2002109566 date "2009-01-01" @default.
• W2002109566 modified "2023-10-17" @default.
• W2002109566 title "ALLOGENEIC STEM CELL TRANSPLANTATION FOR MYELODYSPLASTIC SYNDROMES IN CHILDREN: A Report from the Spanish Working Party for Blood and Marrow Transplantation in Children (GETMON)" @default.
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• W2002109566 doi "https://doi.org/10.1080/08880010902976742" @default.
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