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• W2002112818 startingPage "1067" @default.
• W2002112818 abstract "In very recent years, polyaniline or its derivatives have been adopted to efficiently immobilize probe DNA via π–π interaction between conjugated interface and DNA bases. In this work, self-doped polyaniline (SPAN)–DNA hybrid was adopted as the platform to construct a DNA biosensor with label-free, reagentless and electrochemical self-signal amplifying features. This was achieved by the π–π interaction between conjugated SPAN and DNA bases, also the intrinsic differences between single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The tightly cross-linked hybrid was tethered to Au electrode, which had been anchored by p-aminothiophenol (PATP) self-assembled monolayer (SAM) previously, based on the phosphoramidate bond between PATP and ssDNA. SPAN in the recognition surface exhibited well-defined redox signals under neutral conditions. Due to the intrinsic property differences between ssDNA and dsDNA, such as rigidity, π-stacked bases, charge distribution and long-range electron transfer, SPAN–DNA underwent a major conformational change after hybridization. The redox behaviors of SPAN were modulated by DNA, which served as signals to monitor hybridization. As an example, the gene fragment related to one of the screening genes for the genetically modified plants, cauliflower mosaic virus 35S gene was satisfactorily detected with this strategy. Under optimal conditions, the dynamic range for the DNA assay was from 1.0 × 10−14 mol L−1 to 1.0 × 10−8 mol L−1 with the detection limit of 2.3 × 10−15 mol L−1. This work presents the construction of a recognition surface for the highly-sensitive electrochemical DNA hybridization detection via the self-signal amplifying procedure of conjugated SPAN–DNA hybrid. Unlike most signal amplifying processes using outer indicators, complex labels or other reagents, this procedure possesses simplicity and convenience." @default.
• W2002112818 created "2016-06-24" @default.
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• W2002112818 date "2013-01-01" @default.
• W2002112818 modified "2023-10-16" @default.
• W2002112818 title "Conjugated self-doped polyaniline–DNA hybrid as trigger for highly sensitive reagentless and electrochemical self-signal amplifying DNA hybridization sensing" @default.
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• W2002112818 doi "https://doi.org/10.1039/c2an36620g" @default.
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