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• W2002112900 abstract "MicroRNAs regulate self renewal and differentiation of cancer stem cells. There, we sought to identify the expression of miR-181b in glioma stem cells and investigate the biological effect of miR-181b on glioma stem cells in this study. MiR-181b expression was measured by real-time PCR in glioma stem cells isolated from U87 cells by FACS sorting. After miR-181b was overexpressed in U87 glioma stem cells by miR-181b lentiviral expression vector and/or treatment of temozolomide, secondary neurosphere assay, soft agar colony assay and MTT assay were performed. Compared with U87 cells, the expression of miR-181b was significantly decreased in U87 glioma stem cells. Overexpression of miR-181b decreased neurosphere formation by U87 glioma stem cells in vitro and suppressed colony formation in soft agar, and the cell growth inhibition rates increased in a time-dependent manner in U87 glioma stem cells infected with miR-181b lentivirus. Furthermore, miR-181b had a synergistic effect on temozolomide-induced inhibition of secondary neurosphere and soft agar colony, and on cell growth inhibition rates. MiR-181b functions as a tumor suppressor that suppresses proliferation and reduces chemoresistance to temozolomide in glioma stem cells." @default.
• W2002112900 created "2016-06-24" @default.
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• W2002112900 date "2010-11-01" @default.
• W2002112900 modified "2023-10-16" @default.
• W2002112900 title "MiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells" @default.
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• W2002112900 doi "https://doi.org/10.1016/s1674-8301(10)60058-9" @default.
• W2002112900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3596691" @default.
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