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- W2002113146 abstract "Pyrazolopyridines, such as etazolate (SQ 20009), enhance [3H]diazepam binding to a Lubrol-solubilized fraction that has specific binding sites for 3H benzodiazepines, [alpha-3H]dihydropicrotoxinin (DHP) and [3H]muscimol. Etazolate enhancement of [3H]diazepam binding was inhibited by picrotoxinin. Furthermore, etazolate inhibited the [3H]DHP binding in a Lubrol-solubilized fraction with an IC50 value of 6-8 microM. These results provide evidence that etazolate, like pentobarbital, modulates benzodiazepine binding via the DHP-sensitive site of the benzodiazepine-GABA receptor-ionophore complex." @default.
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- W2002113146 date "1982-04-01" @default.
- W2002113146 modified "2023-09-23" @default.
- W2002113146 title "Molecular Interactions of Etazolate with Benzodiazepine and Picrotoxinin Binding Sites" @default.
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- W2002113146 doi "https://doi.org/10.1111/j.1471-4159.1982.tb05370.x" @default.
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