Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002113178> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2002113178 endingPage "1212" @default.
- W2002113178 startingPage "1211" @default.
- W2002113178 abstract "The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these two apparently opposing models, demonstrating that pancreatic progenitors re-localize to establish the niche that will determine their ultimate fate. We identify a p120ctn-regulated mechanism for coordination of organ architecture and cellular fate mediated by differential E-cadherin based cell sorting. Reduced p120ctn expression is necessary and sufficient to re-localize a subset of progenitors to the peripheral tip domain, where they acquire an acinar fate. The same mechanism is used re-iteratively during endocrine specification, where it balances the choice between the alpha and beta cell fates. In conclusion, organ patterning is regulated by p120ctn-mediated cellular positioning, which precedes and determines pancreatic progenitor fate." @default.
- W2002113178 created "2016-06-24" @default.
- W2002113178 creator A5002320368 @default.
- W2002113178 creator A5053689963 @default.
- W2002113178 creator A5069031914 @default.
- W2002113178 creator A5081043590 @default.
- W2002113178 creator A5087462267 @default.
- W2002113178 date "2006-09-01" @default.
- W2002113178 modified "2023-09-27" @default.
- W2002113178 title "Pseudothrombocytes detected by two-color flowcytometry in acute lymphoblastic leukemia (ALL-L3)" @default.
- W2002113178 cites W1861332340 @default.
- W2002113178 cites W2016212809 @default.
- W2002113178 cites W2097567402 @default.
- W2002113178 cites W2315928129 @default.
- W2002113178 cites W2014564013 @default.
- W2002113178 doi "https://doi.org/10.1016/j.leukres.2005.12.002" @default.
- W2002113178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16494943" @default.
- W2002113178 hasPublicationYear "2006" @default.
- W2002113178 type Work @default.
- W2002113178 sameAs 2002113178 @default.
- W2002113178 citedByCount "0" @default.
- W2002113178 crossrefType "journal-article" @default.
- W2002113178 hasAuthorship W2002113178A5002320368 @default.
- W2002113178 hasAuthorship W2002113178A5053689963 @default.
- W2002113178 hasAuthorship W2002113178A5069031914 @default.
- W2002113178 hasAuthorship W2002113178A5081043590 @default.
- W2002113178 hasAuthorship W2002113178A5087462267 @default.
- W2002113178 hasConcept C104317684 @default.
- W2002113178 hasConcept C111472728 @default.
- W2002113178 hasConcept C134018914 @default.
- W2002113178 hasConcept C138885662 @default.
- W2002113178 hasConcept C15729860 @default.
- W2002113178 hasConcept C163952510 @default.
- W2002113178 hasConcept C201750760 @default.
- W2002113178 hasConcept C28328180 @default.
- W2002113178 hasConcept C46699223 @default.
- W2002113178 hasConcept C54355233 @default.
- W2002113178 hasConcept C71315377 @default.
- W2002113178 hasConcept C86339819 @default.
- W2002113178 hasConcept C86803240 @default.
- W2002113178 hasConcept C89611455 @default.
- W2002113178 hasConcept C95444343 @default.
- W2002113178 hasConceptScore W2002113178C104317684 @default.
- W2002113178 hasConceptScore W2002113178C111472728 @default.
- W2002113178 hasConceptScore W2002113178C134018914 @default.
- W2002113178 hasConceptScore W2002113178C138885662 @default.
- W2002113178 hasConceptScore W2002113178C15729860 @default.
- W2002113178 hasConceptScore W2002113178C163952510 @default.
- W2002113178 hasConceptScore W2002113178C201750760 @default.
- W2002113178 hasConceptScore W2002113178C28328180 @default.
- W2002113178 hasConceptScore W2002113178C46699223 @default.
- W2002113178 hasConceptScore W2002113178C54355233 @default.
- W2002113178 hasConceptScore W2002113178C71315377 @default.
- W2002113178 hasConceptScore W2002113178C86339819 @default.
- W2002113178 hasConceptScore W2002113178C86803240 @default.
- W2002113178 hasConceptScore W2002113178C89611455 @default.
- W2002113178 hasConceptScore W2002113178C95444343 @default.
- W2002113178 hasIssue "9" @default.
- W2002113178 hasLocation W20021131781 @default.
- W2002113178 hasLocation W20021131782 @default.
- W2002113178 hasOpenAccess W2002113178 @default.
- W2002113178 hasPrimaryLocation W20021131781 @default.
- W2002113178 hasRelatedWork W1947205861 @default.
- W2002113178 hasRelatedWork W1951625267 @default.
- W2002113178 hasRelatedWork W2028593002 @default.
- W2002113178 hasRelatedWork W2039366233 @default.
- W2002113178 hasRelatedWork W2128088703 @default.
- W2002113178 hasRelatedWork W2136283819 @default.
- W2002113178 hasRelatedWork W2531047848 @default.
- W2002113178 hasRelatedWork W2555843614 @default.
- W2002113178 hasRelatedWork W2594618006 @default.
- W2002113178 hasRelatedWork W4292755786 @default.
- W2002113178 hasVolume "30" @default.
- W2002113178 isParatext "false" @default.
- W2002113178 isRetracted "false" @default.
- W2002113178 magId "2002113178" @default.
- W2002113178 workType "article" @default.