FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002113368> ?p ?o ?g. }

• W2002113368 endingPage "103" @default.
• W2002113368 startingPage "96" @default.
• W2002113368 abstract "The conflict between the needs to encode both a protein (impaired by non-synonymous mutation), and nucleic acid structure (impaired by synonymous or non-synonymous mutation), can sometimes be resolved in favour of the nucleic acid because its structure is critical for a selectively advantageous genome-wide activity – recombination. However, above a sequence difference threshold, recombination is impaired. It may then be advantageous for new species to arise. Building on the work of Grantham and others critical of the neutralist viewpoint, heuristic support for this hypothesis emerged from studies of the base composition and structure of retroviral genomes. The extreme enrichment in the purine A of the RNA of human immunodeficiency virus (HIV-1), parallels the mild purine-loading of the RNAs of most organisms, for which there is an adaptive explanation – immune evasion. However, human T cell leukaemia virus (HTLV-1), with the potential to invade the same host cell, shows extreme enrichment in the pyrimidine C. Assuming the low GC% HIV and the high GC% HTLV-1 to share a common ancestor, it was postulated that differences in GC% had arisen to prevent homologous recombination between these emerging lentiviral species. Sympatrically isolated by this intracellular reproductive barrier, prototypic HIV-1 seized the AU-rich (low GC%) high ground (thus committing to purine A rather than purine G). Prototypic HTLV-1 forwent this advantage and evolved an independent evolutionary strategy – similar to that of the GC%-rich Epstein-Barr virus – profound latency maintained by transcription of one purine-rich mRNA. The evidence supporting these interpretations is reviewed." @default.
• W2002113368 created "2016-06-24" @default.
• W2002113368 creator A5048610813 @default.
• W2002113368 date "2014-02-01" @default.
• W2002113368 modified "2023-09-24" @default.
• W2002113368 title "Implications of HIV RNA structure for recombination, speciation, and the neutralism-selectionism controversy" @default.
• W2002113368 cites W1764288588 @default.
• W2002113368 cites W1965850069 @default.
• W2002113368 cites W1969541700 @default.
• W2002113368 cites W1981183703 @default.
• W2002113368 cites W1983465033 @default.
• W2002113368 cites W1983519005 @default.
• W2002113368 cites W1986146966 @default.
• W2002113368 cites W1986946432 @default.
• W2002113368 cites W1993351732 @default.
• W2002113368 cites W1993689095 @default.
• W2002113368 cites W1998849751 @default.
• W2002113368 cites W1999389497 @default.
• W2002113368 cites W2009903504 @default.
• W2002113368 cites W2011503252 @default.
• W2002113368 cites W2014994812 @default.
• W2002113368 cites W2017192552 @default.
• W2002113368 cites W2022049404 @default.
• W2002113368 cites W2022591458 @default.
• W2002113368 cites W2027769711 @default.
• W2002113368 cites W2028322261 @default.
• W2002113368 cites W2032136448 @default.
• W2002113368 cites W2032735163 @default.
• W2002113368 cites W2052374286 @default.
• W2002113368 cites W2058302605 @default.
• W2002113368 cites W2058462301 @default.
• W2002113368 cites W2061771549 @default.
• W2002113368 cites W2073820007 @default.
• W2002113368 cites W2075318054 @default.
• W2002113368 cites W2077488043 @default.
• W2002113368 cites W2078059232 @default.
• W2002113368 cites W2078419878 @default.
• W2002113368 cites W2079009490 @default.
• W2002113368 cites W2079011578 @default.
• W2002113368 cites W2087339944 @default.
• W2002113368 cites W2089115165 @default.
• W2002113368 cites W2091245102 @default.
• W2002113368 cites W2091793144 @default.
• W2002113368 cites W2096717068 @default.
• W2002113368 cites W2096794279 @default.
• W2002113368 cites W2097532103 @default.
• W2002113368 cites W2099219682 @default.
• W2002113368 cites W2104290180 @default.
• W2002113368 cites W2105898752 @default.
• W2002113368 cites W2107257442 @default.
• W2002113368 cites W2123716777 @default.
• W2002113368 cites W2125447804 @default.
• W2002113368 cites W2136166906 @default.
• W2002113368 cites W2136804493 @default.
• W2002113368 cites W2143908068 @default.
• W2002113368 cites W2148959513 @default.
• W2002113368 cites W2150739299 @default.
• W2002113368 cites W2151053994 @default.
• W2002113368 cites W2154160792 @default.
• W2002113368 cites W2170129597 @default.
• W2002113368 cites W3193154502 @default.
• W2002113368 cites W646192874 @default.
• W2002113368 doi "https://doi.org/10.1016/j.micinf.2013.10.017" @default.
• W2002113368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24211872" @default.
• W2002113368 hasPublicationYear "2014" @default.
• W2002113368 type Work @default.
• W2002113368 sameAs 2002113368 @default.
• W2002113368 citedByCount "16" @default.
• W2002113368 countsByYear W20021133682014 @default.
• W2002113368 countsByYear W20021133682016 @default.
• W2002113368 countsByYear W20021133682019 @default.
• W2002113368 countsByYear W20021133682020 @default.
• W2002113368 countsByYear W20021133682021 @default.
• W2002113368 countsByYear W20021133682022 @default.
• W2002113368 crossrefType "journal-article" @default.
• W2002113368 hasAuthorship W2002113368A5048610813 @default.
• W2002113368 hasBestOaLocation W20021133682 @default.
• W2002113368 hasConcept C104317684 @default.
• W2002113368 hasConcept C126142528 @default.
• W2002113368 hasConcept C141231307 @default.
• W2002113368 hasConcept C156695909 @default.
• W2002113368 hasConcept C159047783 @default.
• W2002113368 hasConcept C181199279 @default.
• W2002113368 hasConcept C24107716 @default.
• W2002113368 hasConcept C2776476023 @default.
• W2002113368 hasConcept C54355233 @default.
• W2002113368 hasConcept C55493867 @default.
• W2002113368 hasConcept C67705224 @default.
• W2002113368 hasConcept C86803240 @default.
• W2002113368 hasConcept C89604277 @default.
• W2002113368 hasConceptScore W2002113368C104317684 @default.
• W2002113368 hasConceptScore W2002113368C126142528 @default.
• W2002113368 hasConceptScore W2002113368C141231307 @default.
• W2002113368 hasConceptScore W2002113368C156695909 @default.
• W2002113368 hasConceptScore W2002113368C159047783 @default.
• W2002113368 hasConceptScore W2002113368C181199279 @default.
• W2002113368 hasConceptScore W2002113368C24107716 @default.
• W2002113368 hasConceptScore W2002113368C2776476023 @default.

• next