FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002113371> ?p ?o ?g. }

• W2002113371 endingPage "686" @default.
• W2002113371 startingPage "678" @default.
• W2002113371 abstract "Cellular senescence represents a powerful tumor suppressor mechanism to prevent proliferation and invasion of malignant cells. Since tumor cells as well as primary fibroblasts lacking the lysosomal cysteine-type carboxypeptidase cathepsin X exhibit a reduced invasive capacity, we hypothesized that the underlying reason may be the induction of cellular senescence. To investigate the cellular and molecular mechanisms leading to diminished migration/invasion of cathepsin X-deficient cells, we have analyzed murine embryonic fibroblasts (MEF) derived from cathepsin X-deficient mice and neonatal human dermal fibroblasts (NHDF) transfected with siRNAs targeting cathepsin X. Remarkably, both cell types exhibited a flattened and enlarged cell body, a characteristic phenotype of senescent cells. Additional evidence for accelerated senescence was obtained by detection of the common senescence marker β-galactosidase. Further examination revealed increased expression levels of senescence-associated genes such as p16, p21, p53, and caveolin in these cells along with a reduced proliferation rate. The accelerated cellular senescence induced by cathepsin X deficiency was rescued by simultaneous expression of exogenous cathepsin X. Finally, cell cycle analysis confirmed a marked reduction of the synthesis rate and prolongation of the S-phase, while susceptibility to apoptosis of cathepsin X-deficient cells remained unchanged. In conclusion, cathepsin X deficiency leads to accelerated cellular senescence and consequently to diminished cellular proliferation and migration/invasion implying a potential role of cathepsin X in bypassing cellular senescence." @default.
• W2002113371 created "2016-06-24" @default.
• W2002113371 creator A5007054466 @default.
• W2002113371 creator A5035296329 @default.
• W2002113371 creator A5054315140 @default.
• W2002113371 creator A5055275200 @default.
• W2002113371 creator A5056167966 @default.
• W2002113371 creator A5056750884 @default.
• W2002113371 creator A5061376363 @default.
• W2002113371 creator A5090709664 @default.
• W2002113371 creator A5017025263 @default.
• W2002113371 date "2011-08-01" @default.
• W2002113371 modified "2023-10-14" @default.
• W2002113371 title "Cellular senescence induced by cathepsin X downregulation" @default.
• W2002113371 cites W1541154872 @default.
• W2002113371 cites W1810397483 @default.
• W2002113371 cites W1898732028 @default.
• W2002113371 cites W1903338939 @default.
• W2002113371 cites W1970924670 @default.
• W2002113371 cites W1977812451 @default.
• W2002113371 cites W1996966832 @default.
• W2002113371 cites W1997484584 @default.
• W2002113371 cites W1998397829 @default.
• W2002113371 cites W1999630747 @default.
• W2002113371 cites W2009111984 @default.
• W2002113371 cites W2009694614 @default.
• W2002113371 cites W2014646239 @default.
• W2002113371 cites W2019681593 @default.
• W2002113371 cites W2019903459 @default.
• W2002113371 cites W2023179617 @default.
• W2002113371 cites W2024209230 @default.
• W2002113371 cites W2028331505 @default.
• W2002113371 cites W2036676765 @default.
• W2002113371 cites W2050551830 @default.
• W2002113371 cites W2055755257 @default.
• W2002113371 cites W2059977705 @default.
• W2002113371 cites W2062107951 @default.
• W2002113371 cites W2064428770 @default.
• W2002113371 cites W2067379150 @default.
• W2002113371 cites W2084484454 @default.
• W2002113371 cites W2086531624 @default.
• W2002113371 cites W2090985686 @default.
• W2002113371 cites W2094887156 @default.
• W2002113371 cites W2100412031 @default.
• W2002113371 cites W2100837269 @default.
• W2002113371 cites W2104908670 @default.
• W2002113371 cites W2107264101 @default.
• W2002113371 cites W2107488926 @default.
• W2002113371 cites W2121571714 @default.
• W2002113371 cites W2132399579 @default.
• W2002113371 cites W2143747809 @default.
• W2002113371 cites W2159984962 @default.
• W2002113371 cites W2163207898 @default.
• W2002113371 cites W2165097920 @default.
• W2002113371 doi "https://doi.org/10.1016/j.ejcb.2011.03.008" @default.
• W2002113371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21616554" @default.
• W2002113371 hasPublicationYear "2011" @default.
• W2002113371 type Work @default.
• W2002113371 sameAs 2002113371 @default.
• W2002113371 citedByCount "22" @default.
• W2002113371 countsByYear W20021133712012 @default.
• W2002113371 countsByYear W20021133712013 @default.
• W2002113371 countsByYear W20021133712014 @default.
• W2002113371 countsByYear W20021133712015 @default.
• W2002113371 countsByYear W20021133712017 @default.
• W2002113371 countsByYear W20021133712018 @default.
• W2002113371 countsByYear W20021133712019 @default.
• W2002113371 countsByYear W20021133712021 @default.
• W2002113371 countsByYear W20021133712022 @default.
• W2002113371 crossrefType "journal-article" @default.
• W2002113371 hasAuthorship W2002113371A5007054466 @default.
• W2002113371 hasAuthorship W2002113371A5017025263 @default.
• W2002113371 hasAuthorship W2002113371A5035296329 @default.
• W2002113371 hasAuthorship W2002113371A5054315140 @default.
• W2002113371 hasAuthorship W2002113371A5055275200 @default.
• W2002113371 hasAuthorship W2002113371A5056167966 @default.
• W2002113371 hasAuthorship W2002113371A5056750884 @default.
• W2002113371 hasAuthorship W2002113371A5061376363 @default.
• W2002113371 hasAuthorship W2002113371A5090709664 @default.
• W2002113371 hasConcept C101990758 @default.
• W2002113371 hasConcept C104317684 @default.
• W2002113371 hasConcept C127561419 @default.
• W2002113371 hasConcept C153911025 @default.
• W2002113371 hasConcept C167844969 @default.
• W2002113371 hasConcept C173633252 @default.
• W2002113371 hasConcept C181199279 @default.
• W2002113371 hasConcept C190283241 @default.
• W2002113371 hasConcept C202751555 @default.
• W2002113371 hasConcept C2776033226 @default.
• W2002113371 hasConcept C2780034444 @default.
• W2002113371 hasConcept C28021979 @default.
• W2002113371 hasConcept C29537977 @default.
• W2002113371 hasConcept C522857546 @default.
• W2002113371 hasConcept C54009773 @default.
• W2002113371 hasConcept C54355233 @default.
• W2002113371 hasConcept C55493867 @default.
• W2002113371 hasConcept C62112901 @default.
• W2002113371 hasConcept C81885089 @default.

• next