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- W2002115964 abstract "Incubation of racemic serine with the anaerobic bacterium Fusobacterium nucleatum yielded d-serine in high enantiomeric excess (>95%). Selective degradation of the l-amino acid was most efficient when F. nucleatum was resuspended in a buffer at high cell densities (ca. 50–100 g damp cells/L); a single incubation effectively removed almost all l-serine from racemic mixtures at initial concentrations up to 800 mM, the solubility limit. The product d-amino acid was separated from the metabolic end-products (acetate, butyrate and lactate) and buffer components by a single cation-exchange step. After recrystallization, 83% of the d-serine in the initial racemate was recovered with >99% ee (HPLC) and 98% purity (HPLC). This anaerobic microbial approach provides a viable complementary method for generating d-serine, a valuable chiral starting material for chemical synthesis." @default.
- W2002115964 created "2016-06-24" @default.
- W2002115964 creator A5024959498 @default.
- W2002115964 creator A5049264762 @default.
- W2002115964 date "2011-07-01" @default.
- W2002115964 modified "2023-09-27" @default.
- W2002115964 title "Enantioselective catabolism of racemic serine: preparation of d-serine using whole cells of Fusobacterium nucleatum" @default.
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- W2002115964 doi "https://doi.org/10.1016/j.tetasy.2011.07.026" @default.
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