FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002118566> ?p ?o ?g. }

• W2002118566 endingPage "342" @default.
• W2002118566 startingPage "325" @default.
• W2002118566 abstract "Morphology and responses of hepatocytes are investigated using an artificial asialoglycoprotein model polymer-lactose-carrying polystyrene (PVLA) as a culture substratum, especially in focusing on the effect of the surface density of the PVLA substratum. The surface density of PVLA on polystyrene dishes was determined using fluorescein-labeled PVLA as a probe under a fluorescence laser microscope. PVLA-coated surfaces were observed by scanning electron microscope and atomic force microscopies under air and water, which showed that PVLA molecules were adsorbed patchily on low density surfaces and uniformly concentrated all over the dish on high density surfaces. It is suggested from the requirement of the Ca2+ ion, inhibition of galactosyl substances, and localization of receptors that the adhesion of hepatocytes to both low and high PVLA-density surfaces is mediated by galactose-specific interactions between PVLA and asialoglycoprotein receptors. At low PVLA densities (0.07 μg cm-2), the hepatocytes were flat and expressed high levels of 3H-thymidine uptake and low levels of bile acid secretion. Contrastingly, at high PVLA densities (1.08 μg cm-2), they were round and expressed a low level of 3H-thymidine uptake and a high level of bile acid secretion. The shapes, proliferation, and differentiation of hepatocytes could be regulated by varying the densities of PVLA adsorbed to polystyrene dishes. We assume that there are two recognition mechanisms operating between PVLA and hepatocytes: (1) adhesion through highly concentrated or clustered galactose-specific interaction; and (2) responses in shape, proliferation, and differentiation by PVLA-coating densities." @default.
• W2002118566 created "2016-06-24" @default.
• W2002118566 creator A5049582015 @default.
• W2002118566 creator A5056791373 @default.
• W2002118566 creator A5064130864 @default.
• W2002118566 creator A5087663380 @default.
• W2002118566 date "1995-01-01" @default.
• W2002118566 modified "2023-10-16" @default.
• W2002118566 title "Receptor-mediated regulation of differentiation and proliferation of hepatocytes by synthetic polymer model of asialoglycoprotein" @default.
• W2002118566 cites W1490154674 @default.
• W2002118566 cites W1563645938 @default.
• W2002118566 cites W1584315316 @default.
• W2002118566 cites W1953214367 @default.
• W2002118566 cites W1976794059 @default.
• W2002118566 cites W1977665282 @default.
• W2002118566 cites W1979225849 @default.
• W2002118566 cites W1985522024 @default.
• W2002118566 cites W1997335683 @default.
• W2002118566 cites W2004995270 @default.
• W2002118566 cites W2011853969 @default.
• W2002118566 cites W2015284366 @default.
• W2002118566 cites W2018886082 @default.
• W2002118566 cites W2028518884 @default.
• W2002118566 cites W2031960141 @default.
• W2002118566 cites W2049638550 @default.
• W2002118566 cites W2063753069 @default.
• W2002118566 cites W2065365994 @default.
• W2002118566 cites W2090962290 @default.
• W2002118566 cites W2097662759 @default.
• W2002118566 cites W2119271282 @default.
• W2002118566 cites W2399577204 @default.
• W2002118566 cites W95866195 @default.
• W2002118566 doi "https://doi.org/10.1163/156856295x00030" @default.
• W2002118566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7841142" @default.
• W2002118566 hasPublicationYear "1995" @default.
• W2002118566 type Work @default.
• W2002118566 sameAs 2002118566 @default.
• W2002118566 citedByCount "53" @default.
• W2002118566 countsByYear W20021185662012 @default.
• W2002118566 countsByYear W20021185662013 @default.
• W2002118566 countsByYear W20021185662014 @default.
• W2002118566 countsByYear W20021185662015 @default.
• W2002118566 countsByYear W20021185662017 @default.
• W2002118566 countsByYear W20021185662019 @default.
• W2002118566 crossrefType "journal-article" @default.
• W2002118566 hasAuthorship W2002118566A5049582015 @default.
• W2002118566 hasAuthorship W2002118566A5056791373 @default.
• W2002118566 hasAuthorship W2002118566A5064130864 @default.
• W2002118566 hasAuthorship W2002118566A5087663380 @default.
• W2002118566 hasConcept C11569505 @default.
• W2002118566 hasConcept C120665830 @default.
• W2002118566 hasConcept C121332964 @default.
• W2002118566 hasConcept C12554922 @default.
• W2002118566 hasConcept C150394285 @default.
• W2002118566 hasConcept C159985019 @default.
• W2002118566 hasConcept C169274487 @default.
• W2002118566 hasConcept C178790620 @default.
• W2002118566 hasConcept C185592680 @default.
• W2002118566 hasConcept C192562407 @default.
• W2002118566 hasConcept C202751555 @default.
• W2002118566 hasConcept C26771246 @default.
• W2002118566 hasConcept C2776200302 @default.
• W2002118566 hasConcept C2777922577 @default.
• W2002118566 hasConcept C521977710 @default.
• W2002118566 hasConcept C55493867 @default.
• W2002118566 hasConcept C84416704 @default.
• W2002118566 hasConcept C86803240 @default.
• W2002118566 hasConcept C91881484 @default.
• W2002118566 hasConcept C95444343 @default.
• W2002118566 hasConceptScore W2002118566C11569505 @default.
• W2002118566 hasConceptScore W2002118566C120665830 @default.
• W2002118566 hasConceptScore W2002118566C121332964 @default.
• W2002118566 hasConceptScore W2002118566C12554922 @default.
• W2002118566 hasConceptScore W2002118566C150394285 @default.
• W2002118566 hasConceptScore W2002118566C159985019 @default.
• W2002118566 hasConceptScore W2002118566C169274487 @default.
• W2002118566 hasConceptScore W2002118566C178790620 @default.
• W2002118566 hasConceptScore W2002118566C185592680 @default.
• W2002118566 hasConceptScore W2002118566C192562407 @default.
• W2002118566 hasConceptScore W2002118566C202751555 @default.
• W2002118566 hasConceptScore W2002118566C26771246 @default.
• W2002118566 hasConceptScore W2002118566C2776200302 @default.
• W2002118566 hasConceptScore W2002118566C2777922577 @default.
• W2002118566 hasConceptScore W2002118566C521977710 @default.
• W2002118566 hasConceptScore W2002118566C55493867 @default.
• W2002118566 hasConceptScore W2002118566C84416704 @default.
• W2002118566 hasConceptScore W2002118566C86803240 @default.
• W2002118566 hasConceptScore W2002118566C91881484 @default.
• W2002118566 hasConceptScore W2002118566C95444343 @default.
• W2002118566 hasIssue "4" @default.
• W2002118566 hasLocation W20021185661 @default.
• W2002118566 hasLocation W20021185662 @default.
• W2002118566 hasOpenAccess W2002118566 @default.
• W2002118566 hasPrimaryLocation W20021185661 @default.
• W2002118566 hasRelatedWork W2003446143 @default.
• W2002118566 hasRelatedWork W2009185624 @default.
• W2002118566 hasRelatedWork W2016861639 @default.
• W2002118566 hasRelatedWork W2044929494 @default.

• next