FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002118757> ?p ?o ?g. }

• W2002118757 endingPage "52" @default.
• W2002118757 startingPage "47" @default.
• W2002118757 abstract "We evaluated the effect of several K(+) channel blockers on the peripheral antinociception induced by dipyrone using the rat paw pressure test, in which sensitivity is increased by intraplantar injection (2 micro g) of prostaglandin E(2). Dipyrone administered locally into the right hindpaw (50, 100 and 200 micro g) elicited a dose-dependent antinociceptive effect which was demonstrated to be local, since only higher doses produced an effect when injected in the contralateral paw. The specific blockers of ATP-sensitive K(+) channels glibenclamide (40, 80 and 160 micro g/paw) and tolbutamide (80, 160 and 320 micro g/paw) antagonized the peripheral antinociception induced by dipyrone (200 micro g/paw). Charybdotoxin (2 micro g/ paw), a blocker of large conductance Ca(2+)-activated K(+) channels, and dequalinium (50 micro g/paw), a selective blocker of small conductance Ca(2+)-activated K(+) channels, did not modify the effect of dipyrone. This effect was also unaffected neither by intraplantar administration of non-specific voltage-dependent K(+) channel blockers tetraethylammonium (1700 micro g) and 4-aminopyridine (100 micro g) nor cesium (500 micro g), a non-specific K(+) channel blocker. These results suggest that the peripheral antinociceptive effect of dipyrone may result from activation of ATP-sensitive K(+) channels, while other K(+) channels appear not to be involved in the process." @default.
• W2002118757 created "2016-06-24" @default.
• W2002118757 creator A5014108092 @default.
• W2002118757 creator A5049524856 @default.
• W2002118757 date "2002-05-01" @default.
• W2002118757 modified "2023-09-30" @default.
• W2002118757 title "Involvement of ATP-sensitive K+ channels in the peripheral antinociceptive effect induced by dipyrone" @default.
• W2002118757 cites W1979254966 @default.
• W2002118757 cites W1979981300 @default.
• W2002118757 cites W1991670604 @default.
• W2002118757 cites W1992823328 @default.
• W2002118757 cites W1995646618 @default.
• W2002118757 cites W1999908521 @default.
• W2002118757 cites W2003855651 @default.
• W2002118757 cites W2008574207 @default.
• W2002118757 cites W2025034988 @default.
• W2002118757 cites W2031997571 @default.
• W2002118757 cites W2038501092 @default.
• W2002118757 cites W2040393757 @default.
• W2002118757 cites W2040754866 @default.
• W2002118757 cites W2043899013 @default.
• W2002118757 cites W2053933048 @default.
• W2002118757 cites W2056583583 @default.
• W2002118757 cites W2080072795 @default.
• W2002118757 cites W2082304034 @default.
• W2002118757 cites W2090968114 @default.
• W2002118757 cites W2116963442 @default.
• W2002118757 cites W2120011554 @default.
• W2002118757 cites W2166610424 @default.
• W2002118757 cites W4242192243 @default.
• W2002118757 doi "https://doi.org/10.1016/s0014-2999(02)01412-7" @default.
• W2002118757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12191581" @default.
• W2002118757 hasPublicationYear "2002" @default.
• W2002118757 type Work @default.
• W2002118757 sameAs 2002118757 @default.
• W2002118757 citedByCount "121" @default.
• W2002118757 countsByYear W20021187572012 @default.
• W2002118757 countsByYear W20021187572013 @default.
• W2002118757 countsByYear W20021187572014 @default.
• W2002118757 countsByYear W20021187572015 @default.
• W2002118757 countsByYear W20021187572016 @default.
• W2002118757 countsByYear W20021187572017 @default.
• W2002118757 countsByYear W20021187572018 @default.
• W2002118757 countsByYear W20021187572019 @default.
• W2002118757 countsByYear W20021187572020 @default.
• W2002118757 countsByYear W20021187572021 @default.
• W2002118757 countsByYear W20021187572022 @default.
• W2002118757 countsByYear W20021187572023 @default.
• W2002118757 crossrefType "journal-article" @default.
• W2002118757 hasAuthorship W2002118757A5014108092 @default.
• W2002118757 hasAuthorship W2002118757A5049524856 @default.
• W2002118757 hasConcept C126322002 @default.
• W2002118757 hasConcept C134018914 @default.
• W2002118757 hasConcept C153461711 @default.
• W2002118757 hasConcept C15490471 @default.
• W2002118757 hasConcept C170493617 @default.
• W2002118757 hasConcept C178790620 @default.
• W2002118757 hasConcept C181911157 @default.
• W2002118757 hasConcept C185592680 @default.
• W2002118757 hasConcept C2776054734 @default.
• W2002118757 hasConcept C2779768347 @default.
• W2002118757 hasConcept C2780419564 @default.
• W2002118757 hasConcept C2780922449 @default.
• W2002118757 hasConcept C2781295685 @default.
• W2002118757 hasConcept C46762472 @default.
• W2002118757 hasConcept C517785266 @default.
• W2002118757 hasConcept C519063684 @default.
• W2002118757 hasConcept C55493867 @default.
• W2002118757 hasConcept C555293320 @default.
• W2002118757 hasConcept C71924100 @default.
• W2002118757 hasConcept C83743174 @default.
• W2002118757 hasConcept C98274493 @default.
• W2002118757 hasConceptScore W2002118757C126322002 @default.
• W2002118757 hasConceptScore W2002118757C134018914 @default.
• W2002118757 hasConceptScore W2002118757C153461711 @default.
• W2002118757 hasConceptScore W2002118757C15490471 @default.
• W2002118757 hasConceptScore W2002118757C170493617 @default.
• W2002118757 hasConceptScore W2002118757C178790620 @default.
• W2002118757 hasConceptScore W2002118757C181911157 @default.
• W2002118757 hasConceptScore W2002118757C185592680 @default.
• W2002118757 hasConceptScore W2002118757C2776054734 @default.
• W2002118757 hasConceptScore W2002118757C2779768347 @default.
• W2002118757 hasConceptScore W2002118757C2780419564 @default.
• W2002118757 hasConceptScore W2002118757C2780922449 @default.
• W2002118757 hasConceptScore W2002118757C2781295685 @default.
• W2002118757 hasConceptScore W2002118757C46762472 @default.
• W2002118757 hasConceptScore W2002118757C517785266 @default.
• W2002118757 hasConceptScore W2002118757C519063684 @default.
• W2002118757 hasConceptScore W2002118757C55493867 @default.
• W2002118757 hasConceptScore W2002118757C555293320 @default.
• W2002118757 hasConceptScore W2002118757C71924100 @default.
• W2002118757 hasConceptScore W2002118757C83743174 @default.
• W2002118757 hasConceptScore W2002118757C98274493 @default.
• W2002118757 hasIssue "1-2" @default.
• W2002118757 hasLocation W20021187571 @default.
• W2002118757 hasLocation W20021187572 @default.
• W2002118757 hasOpenAccess W2002118757 @default.
• W2002118757 hasPrimaryLocation W20021187571 @default.

• next