FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002121405> ?p ?o ?g. }

• W2002121405 endingPage "348" @default.
• W2002121405 startingPage "339" @default.
• W2002121405 abstract "Abstract We report a new vaccination strategy for squamous cell carcinoma (SCC). The vaccine was prepared by transfer of unfractionated DNA‐fragments (25 kb) from squamous carcinoma cells (KLN205, DBA/2 origin (H‐2 d )) into LM mouse fibroblasts (C3H/He origin; H‐2 k ), a highly immunogenic cell line. To enhance their nonspecific immunogenic properties, the fibroblasts were modified before DNA transfer to secrete IL‐2 and to express additional allogeneic MHC class I determinants. As the transferred DNA integrates into the genome of the recipient cells, and is replicated as the cells divide, sufficient DNA to prepare the vaccine could be obtained from as few as 10 7 squamous carcinoma cells (4 mm tumor). Since only a small proportion of the transfected cell‐population was expected to have incorporated genes specifying antigens associated with the squamous carcinoma cells (TAA), we devised a novel approach to enrich the vaccine for cells that induce immunity to the SCC. Aliquots of the transfected population were divided into 10 small pools (initial inoculums = 1 × 10 3 ). We reasoned that if the starting inoculums were sufficiently small, then the distribution of highly immunogenic and weakly immunogenic cells in each pool would not be the same. Cells from individual pools were allowed to increase in number. A portion of the expanded cell populations were maintained frozen/viable for later recovery. The remaining portions were used to immunize naïve DBA/2 mice. Pools containing greater numbers of immunogenic cells were identified by 2 independent assays. Frozen aliquots of cells from the pool that stimulated immunity to the squamous carcinoma to the greatest extent were recovered and subdivided for additional rounds of immune selection. Enhanced immunity to squamous carcinoma mediated by CD8+ T cells was induced in tumor‐bearing mice treated solely by immunization with the enriched cell‐population. © 2006 Wiley‐Liss, Inc." @default.
• W2002121405 created "2016-06-24" @default.
• W2002121405 creator A5031576950 @default.
• W2002121405 creator A5071407559 @default.
• W2002121405 creator A5079679300 @default.
• W2002121405 creator A5082212705 @default.
• W2002121405 creator A5085038177 @default.
• W2002121405 date "2006-04-27" @default.
• W2002121405 modified "2023-09-29" @default.
• W2002121405 title "Treatment of squamous carcinoma in mice with a vaccine enriched for cells that induce immunity to squamous carcinoma—A new vaccination strategy" @default.
• W2002121405 cites W1543607558 @default.
• W2002121405 cites W1965975552 @default.
• W2002121405 cites W1982981861 @default.
• W2002121405 cites W1986801129 @default.
• W2002121405 cites W1988296620 @default.
• W2002121405 cites W1993379804 @default.
• W2002121405 cites W1996879439 @default.
• W2002121405 cites W2007933632 @default.
• W2002121405 cites W2015575610 @default.
• W2002121405 cites W2019749043 @default.
• W2002121405 cites W2024238253 @default.
• W2002121405 cites W2028085693 @default.
• W2002121405 cites W2030282327 @default.
• W2002121405 cites W2031328967 @default.
• W2002121405 cites W2037335071 @default.
• W2002121405 cites W2054430764 @default.
• W2002121405 cites W2056435027 @default.
• W2002121405 cites W2056763277 @default.
• W2002121405 cites W2059944708 @default.
• W2002121405 cites W2067327980 @default.
• W2002121405 cites W2070400225 @default.
• W2002121405 cites W2072073440 @default.
• W2002121405 cites W2074850697 @default.
• W2002121405 cites W2084099638 @default.
• W2002121405 cites W2085975031 @default.
• W2002121405 cites W2094217947 @default.
• W2002121405 cites W2096615903 @default.
• W2002121405 cites W2114754387 @default.
• W2002121405 cites W2121544045 @default.
• W2002121405 cites W2124430059 @default.
• W2002121405 cites W2126082532 @default.
• W2002121405 cites W2133508418 @default.
• W2002121405 cites W2163270673 @default.
• W2002121405 cites W2171190459 @default.
• W2002121405 cites W2172273197 @default.
• W2002121405 cites W4292856548 @default.
• W2002121405 cites W4313333841 @default.
• W2002121405 cites W4313342430 @default.
• W2002121405 cites W4313376918 @default.
• W2002121405 doi "https://doi.org/10.1002/ijc.21844" @default.
• W2002121405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16477635" @default.
• W2002121405 hasPublicationYear "2006" @default.
• W2002121405 type Work @default.
• W2002121405 sameAs 2002121405 @default.
• W2002121405 citedByCount "7" @default.
• W2002121405 crossrefType "journal-article" @default.
• W2002121405 hasAuthorship W2002121405A5031576950 @default.
• W2002121405 hasAuthorship W2002121405A5071407559 @default.
• W2002121405 hasAuthorship W2002121405A5079679300 @default.
• W2002121405 hasAuthorship W2002121405A5082212705 @default.
• W2002121405 hasAuthorship W2002121405A5085038177 @default.
• W2002121405 hasBestOaLocation W20021214051 @default.
• W2002121405 hasConcept C147483822 @default.
• W2002121405 hasConcept C153911025 @default.
• W2002121405 hasConcept C159047783 @default.
• W2002121405 hasConcept C159654299 @default.
• W2002121405 hasConcept C167508917 @default.
• W2002121405 hasConcept C170627219 @default.
• W2002121405 hasConcept C203014093 @default.
• W2002121405 hasConcept C207936829 @default.
• W2002121405 hasConcept C22070199 @default.
• W2002121405 hasConcept C2780801004 @default.
• W2002121405 hasConcept C2908647359 @default.
• W2002121405 hasConcept C502942594 @default.
• W2002121405 hasConcept C54009773 @default.
• W2002121405 hasConcept C54355233 @default.
• W2002121405 hasConcept C71924100 @default.
• W2002121405 hasConcept C81885089 @default.
• W2002121405 hasConcept C86803240 @default.
• W2002121405 hasConcept C99454951 @default.
• W2002121405 hasConceptScore W2002121405C147483822 @default.
• W2002121405 hasConceptScore W2002121405C153911025 @default.
• W2002121405 hasConceptScore W2002121405C159047783 @default.
• W2002121405 hasConceptScore W2002121405C159654299 @default.
• W2002121405 hasConceptScore W2002121405C167508917 @default.
• W2002121405 hasConceptScore W2002121405C170627219 @default.
• W2002121405 hasConceptScore W2002121405C203014093 @default.
• W2002121405 hasConceptScore W2002121405C207936829 @default.
• W2002121405 hasConceptScore W2002121405C22070199 @default.
• W2002121405 hasConceptScore W2002121405C2780801004 @default.
• W2002121405 hasConceptScore W2002121405C2908647359 @default.
• W2002121405 hasConceptScore W2002121405C502942594 @default.
• W2002121405 hasConceptScore W2002121405C54009773 @default.
• W2002121405 hasConceptScore W2002121405C54355233 @default.
• W2002121405 hasConceptScore W2002121405C71924100 @default.
• W2002121405 hasConceptScore W2002121405C81885089 @default.
• W2002121405 hasConceptScore W2002121405C86803240 @default.
• W2002121405 hasConceptScore W2002121405C99454951 @default.

• next