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- W2002122128 abstract "<i>Objective:</i> This study was conducted to investigate the correlation between spontaneous recurrent miscarriage (RM) and common polymorphisms in angiotensin-converting enzyme <i>(ACE),</i> plasminogen activator inhibitor 1 <i>(PAI-1)</i> and endothelium-derived nitric oxide synthase 3 <i>(NOS3) </i>genes among women experiencing RM in the Gaza Strip. <i>Methods:</i> The presence of these genetic profiles was determined for 100 women who had had at least 3 constitutive abortions and 100 controls without any history of abortion using molecular biological techniques. <i>Results:</i> The <i>ACE</i> D/D polymorphism was present in 49% of the study population and in 54% of the controls (p = 0.479). Similarly, there was no significant difference detected in the distribution of polymorphisms for <i>PAI-1,</i> with the 4G/4G genotype present in the study group and in controls (p = 1.00). <i>NOS3</i> 4a/4a was present in 4% of the study group and in none of the 100 controls (p = 0.123). In this study, we also discovered a new variant in the <i>NOS3</i> gene which was named 4c allele and was encountered in 1 patient and in 1 control subject. <i>Conclusion:</i> There was no significant association between <i>ACE</i> I/D, <i>PAI-1</i> 4G/5G and <i>NOS3</i> 4a/4b and the occurrence of first-trimester RM. In-depth investigation of the association of <i>NOS3</i> 4a/4a with RM is strongly recommended." @default.
- W2002122128 created "2016-06-24" @default.
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- W2002122128 date "2010-01-01" @default.
- W2002122128 modified "2023-10-18" @default.
- W2002122128 title "Polymorphisms in <i>NOS3, ACE </i>and<i> PAI-1</i> Genes and Risk of Spontaneous Recurrent Miscarriage in the Gaza Strip" @default.
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- W2002122128 doi "https://doi.org/10.1159/000273067" @default.
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