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- W2002124400 abstract "An individual's drug abuse pattern is determined by a multitude of factors. Among these, simple pharmacological determinants of within-binge drug consumption are sorely underinvestigated. We therefore determined if within-session operant responsing to the ultra-short-acting mu opioid agonist remifentanil (RMF) was determined by blood or brain RMF levels or changes thereof. Our peri-response analysis did not detect any threshold RMF level, either in blood or in the nucleus accumbens (NAc) core as a deep brain region that might determine a rat's decision to re-emit a response during a multiple-injection drug self-administration session. The peri-response analysis also failed to find any peak RMF level, either in blood or in the NAc core, which could serve as a ceiling level. Thus, our findings strongly suggest that titration of blood or brain RMF levels does not determine a rat's intra-session operant response." @default.
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- W2002124400 date "2006-08-01" @default.
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- W2002124400 title "Peri-Response Pharmacokinetics of Remifentanil during a Self-Administration Session Indicates That Neither Blood nor Brain Levels Are Titrated" @default.
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- W2002124400 doi "https://doi.org/10.1196/annals.1369.050" @default.
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