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- W2002126189 abstract "In 1925, I expressed an opinion in an article in theArchivesconcerning the general significance of the Tay-Sachs form of familial idiocy; 1 I concluded that this is a germ layer disease, marked by the anatomic triad of ectodermal selectivity, segment selectivity and system selectivity. This theory is opposed by the new observations of Bielschowsky 2 and his followers (H. Kufs, B. Sachs) who claim that amaurotic idiocy is nothing more than a partial manifestation of a mesodermic disease, Niemann-Pick's disease, which as a metabolic disease affects the reticuloendothelial system. As a result of this endogenous metabolic disease, a deposition of lipoid substances occurs in the spleen, liver, thymus, suprarenal medulla, pancreas, the endothelial cells of the blood vessels and heart muscle cells; further, one finds fat droplets in the peripheral nerves, the ganglion cells and the spinal ganglia. According to Pick, 3 there is an oversupply (Ueberangebot) of" @default.
- W2002126189 created "2016-06-24" @default.
- W2002126189 creator A5074382476 @default.
- W2002126189 date "1930-10-01" @default.
- W2002126189 modified "2023-09-27" @default.
- W2002126189 title "PATHOGENESIS OF AMAUROTIC IDIOCY" @default.
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- W2002126189 doi "https://doi.org/10.1001/archneurpsyc.1930.02220160101011" @default.
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