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• W2002126950 abstract "Recent evidence suggests that many of the molecular cascades and substrates that contribute to learning-related forms of neuronal plasticity may be conserved across ostensibly disparate model systems. Notably, the facilitation of neuronal excitability and synaptic transmission that contribute to associative learning in Aplysia and Hermissenda, as well as associative LTP in hippocampal CA1 cells, all require (or are enhanced by) the convergence of a transient elevation in intracellular Ca2+ with transmitter binding to metabotropic cell-surface receptors. This temporal convergence of Ca2+ and G-protein-stimulated second-messenger cascades synergistically stimulates several classes of serine/threonine protein kinases, which in turn modulate receptor function or cell excitability through the phosphorylation of ion channels. We present a summary of the biophysical and molecular constituents of neuronal and synaptic facilitation in each of these three model systems. Although specific components of the underlying molecular cascades differ across these three systems, fundamental aspects of these cascades are widely conserved, leading to the conclusion that the conceptual semblance of these superficially disparate systems is far greater than is generally acknowledged. We suggest that the elucidation of mechanistic similarities between different systems will ultimately fulfill the goal of the model systems approach, that is, the description of critical and ubiquitous features of neuronal and synaptic events that contribute to memory induction." @default.
• W2002126950 created "2016-06-24" @default.
• W2002126950 creator A5001695399 @default.
• W2002126950 creator A5038284282 @default.
• W2002126950 creator A5063681021 @default.
• W2002126950 creator A5070315636 @default.
• W2002126950 date "1998-01-01" @default.
• W2002126950 modified "2023-10-14" @default.
• W2002126950 title "Ubiquitous Molecular Substrates for Associative Learning and Activity-Dependent Neuronal Facilitation" @default.
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