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- W2002127002 abstract "The binding of propranolol enantiomers to human alpha1-acid glycoprotein was studied using high performance liquid chromatography in order to provide insight into binding models and to describe individual binding parameters of both enantiomers. The binding of (−)-propranolol was shown to be saturable with one major binding site (n = 0.81, k = 2.73 × 105/M). The saturation process achieved its upper asymptotic value at drug/protein molar ratio of approximately 1. In the case of the opposite (+)- enantiomer the binding isotherm did not show evidence of saturation even at higher drug/protein molar ratios (up to 50). The individual binding parameters for (+)-enantiomer were n = 0.38, k = 3.4 × 106/M and n′k′ = 1.39 × 104/M for the saturable and nonsaturable binding component, respectively. At drug/protein molar ratio 2 the circular dichroism measurements confirmed the existence of different binding models for individual propranolol enantiomers." @default.
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- W2002127002 title "Different binding of propranolol enantiomers to human alpha1-acid glycoprotein" @default.
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- W2002127002 doi "https://doi.org/10.1016/0006-2952(89)90540-6" @default.
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