FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002127906> ?p ?o ?g. }

• W2002127906 endingPage "146" @default.
• W2002127906 startingPage "138" @default.
• W2002127906 abstract "We present a novel, multiparametric microphysiometry system for the dynamic online monitoring of human cancer cell metabolism. The optically transparent, modular, hybrid microsystem is based on a glass chip and combines a cell cultivation chamber, microfluidics and metabolic monitoring with fully integrated chemo- and biosensors. pH and oxygen are measured in the cell culture area, and biosensors for lactate and glucose are connected downstream by microfluidics. The wafer-level fabrication features thin-film platinum and iridium oxide microelectrodes on a glass chip, microfluidics in an epoxy resist, a hybrid assembly and an on-chip reference electrode. The reliable analytical performance of the sensors in cell culture medium was demonstrated. The pH sensors exhibit a long-term stable, linear response. The oxygen sensors show a linear behaviour, which is also observed for low oxygen concentrations. Glucose and lactate measurements show a linear, long-term stable, selective and reversible behaviour in the desired range. T98G human brain cancer cells were cultivated and cell culture metabolism was measured on-chip. Stop/flow cycles were applied and extracellular acidification, respiration, glucose consumption and lactate production were quantified. Long-term metabolic rates were determined and all parameters could be measured in the outlet channel. A placement downstream of the cell cultivation area for biosensors was realised. A highly effective medium exchange and undiluted sampling from the cell culture chamber with low flow rates (2 μl min−1) and low volumes (15 μl per cycle) were achieved. The drug screening application was demonstrated by detecting alteration and recovery effects of cellular metabolism induced by the addition of substances to the medium." @default.
• W2002127906 created "2016-06-24" @default.
• W2002127906 creator A5002127332 @default.
• W2002127906 creator A5023419233 @default.
• W2002127906 creator A5031047855 @default.
• W2002127906 creator A5044520105 @default.
• W2002127906 creator A5056300578 @default.
• W2002127906 creator A5060342970 @default.
• W2002127906 creator A5069103387 @default.
• W2002127906 creator A5083075685 @default.
• W2002127906 date "2014-01-01" @default.
• W2002127906 modified "2023-10-16" @default.
• W2002127906 title "Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem" @default.
• W2002127906 cites W1242262069 @default.
• W2002127906 cites W1971457265 @default.
• W2002127906 cites W1977486054 @default.
• W2002127906 cites W1986558546 @default.
• W2002127906 cites W1991287097 @default.
• W2002127906 cites W2034179902 @default.
• W2002127906 cites W2035621346 @default.
• W2002127906 cites W2068987819 @default.
• W2002127906 cites W2071984768 @default.
• W2002127906 cites W2074218340 @default.
• W2002127906 cites W2074220779 @default.
• W2002127906 cites W2074236486 @default.
• W2002127906 cites W2078886621 @default.
• W2002127906 cites W2081559745 @default.
• W2002127906 cites W2083323601 @default.
• W2002127906 cites W2091993202 @default.
• W2002127906 cites W2095301069 @default.
• W2002127906 cites W2102716430 @default.
• W2002127906 cites W2110611202 @default.
• W2002127906 cites W2136299255 @default.
• W2002127906 doi "https://doi.org/10.1039/c3lc50759a" @default.
• W2002127906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24217869" @default.
• W2002127906 hasPublicationYear "2014" @default.
• W2002127906 type Work @default.
• W2002127906 sameAs 2002127906 @default.
• W2002127906 citedByCount "211" @default.
• W2002127906 countsByYear W20021279062014 @default.
• W2002127906 countsByYear W20021279062015 @default.
• W2002127906 countsByYear W20021279062016 @default.
• W2002127906 countsByYear W20021279062017 @default.
• W2002127906 countsByYear W20021279062018 @default.
• W2002127906 countsByYear W20021279062019 @default.
• W2002127906 countsByYear W20021279062020 @default.
• W2002127906 countsByYear W20021279062021 @default.
• W2002127906 countsByYear W20021279062022 @default.
• W2002127906 countsByYear W20021279062023 @default.
• W2002127906 crossrefType "journal-article" @default.
• W2002127906 hasAuthorship W2002127906A5002127332 @default.
• W2002127906 hasAuthorship W2002127906A5023419233 @default.
• W2002127906 hasAuthorship W2002127906A5031047855 @default.
• W2002127906 hasAuthorship W2002127906A5044520105 @default.
• W2002127906 hasAuthorship W2002127906A5056300578 @default.
• W2002127906 hasAuthorship W2002127906A5060342970 @default.
• W2002127906 hasAuthorship W2002127906A5069103387 @default.
• W2002127906 hasAuthorship W2002127906A5083075685 @default.
• W2002127906 hasConcept C109156525 @default.
• W2002127906 hasConcept C111670793 @default.
• W2002127906 hasConcept C147789679 @default.
• W2002127906 hasConcept C151054161 @default.
• W2002127906 hasConcept C160756335 @default.
• W2002127906 hasConcept C171250308 @default.
• W2002127906 hasConcept C17525397 @default.
• W2002127906 hasConcept C185592680 @default.
• W2002127906 hasConcept C192562407 @default.
• W2002127906 hasConcept C20251656 @default.
• W2002127906 hasConcept C55493867 @default.
• W2002127906 hasConcept C62231903 @default.
• W2002127906 hasConcept C8673954 @default.
• W2002127906 hasConceptScore W2002127906C109156525 @default.
• W2002127906 hasConceptScore W2002127906C111670793 @default.
• W2002127906 hasConceptScore W2002127906C147789679 @default.
• W2002127906 hasConceptScore W2002127906C151054161 @default.
• W2002127906 hasConceptScore W2002127906C160756335 @default.
• W2002127906 hasConceptScore W2002127906C171250308 @default.
• W2002127906 hasConceptScore W2002127906C17525397 @default.
• W2002127906 hasConceptScore W2002127906C185592680 @default.
• W2002127906 hasConceptScore W2002127906C192562407 @default.
• W2002127906 hasConceptScore W2002127906C20251656 @default.
• W2002127906 hasConceptScore W2002127906C55493867 @default.
• W2002127906 hasConceptScore W2002127906C62231903 @default.
• W2002127906 hasConceptScore W2002127906C8673954 @default.
• W2002127906 hasIssue "1" @default.
• W2002127906 hasLocation W20021279061 @default.
• W2002127906 hasLocation W20021279062 @default.
• W2002127906 hasOpenAccess W2002127906 @default.
• W2002127906 hasPrimaryLocation W20021279061 @default.
• W2002127906 hasRelatedWork W1495423923 @default.
• W2002127906 hasRelatedWork W1988460209 @default.
• W2002127906 hasRelatedWork W2005078723 @default.
• W2002127906 hasRelatedWork W2242980981 @default.
• W2002127906 hasRelatedWork W2289396372 @default.
• W2002127906 hasRelatedWork W2291723222 @default.
• W2002127906 hasRelatedWork W2884343688 @default.
• W2002127906 hasRelatedWork W4253324731 @default.
• W2002127906 hasRelatedWork W4324119913 @default.

• next