Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002128807> ?p ?o ?g. }
- W2002128807 endingPage "115" @default.
- W2002128807 startingPage "107" @default.
- W2002128807 abstract "Aged rats were chronically administered acetyl-L-carnitine (AC) for 10 months. During this period they were tested on learning and sensorimotor tasks and were then subsequently tested electrophysiologically to assess induction and decay rates of long-term synaptic enhancement (LTE) in the hippocampus. Four groups were tested: young controls (4 mo-con), middle-aged controls (16 mo-con), old controls (24 mo-con), and old AC-treated rats (24 mo-AC). After completion of electrophysiological testing, each rat was sacrificed and investigated for age- or drug-related changes in three neurotransmitter markers; including, NMDA-sensitive glutamate receptors, high affinity choline uptake, and adenosine receptor number in the neocortex, hippocampus or caudate nucleus. Aging impaired spatial learning and there was a robust positive correlation between NMDA receptors in the hippocampus and acquisition of the spatial learning task. Induction of hippocampal LTE was reduced in 24 mo-AC rats and NMDA receptor number and high-affinity choline uptake in the frontal cortex was increased. Several suggestions are offered to explain the action of AC on these neurobiological parameters in old rats." @default.
- W2002128807 created "2016-06-24" @default.
- W2002128807 creator A5039247811 @default.
- W2002128807 creator A5042422785 @default.
- W2002128807 creator A5070236497 @default.
- W2002128807 creator A5079424184 @default.
- W2002128807 date "1993-01-01" @default.
- W2002128807 modified "2023-09-23" @default.
- W2002128807 title "Acetyl-l-carnitine: Behavioral, electrophysiological, and neurochemical effects" @default.
- W2002128807 cites W1504073232 @default.
- W2002128807 cites W1577989916 @default.
- W2002128807 cites W1775749144 @default.
- W2002128807 cites W1966755170 @default.
- W2002128807 cites W1972088226 @default.
- W2002128807 cites W1972611197 @default.
- W2002128807 cites W1973537752 @default.
- W2002128807 cites W1974763192 @default.
- W2002128807 cites W1977047599 @default.
- W2002128807 cites W1978018256 @default.
- W2002128807 cites W1980239800 @default.
- W2002128807 cites W1983021005 @default.
- W2002128807 cites W1983923341 @default.
- W2002128807 cites W1988150609 @default.
- W2002128807 cites W1990952243 @default.
- W2002128807 cites W1992294190 @default.
- W2002128807 cites W2006328529 @default.
- W2002128807 cites W2009782005 @default.
- W2002128807 cites W2010128461 @default.
- W2002128807 cites W2011306095 @default.
- W2002128807 cites W2011974449 @default.
- W2002128807 cites W2016261700 @default.
- W2002128807 cites W2017169966 @default.
- W2002128807 cites W2019209361 @default.
- W2002128807 cites W2019402991 @default.
- W2002128807 cites W2025734752 @default.
- W2002128807 cites W2025801062 @default.
- W2002128807 cites W2031003228 @default.
- W2002128807 cites W2031674150 @default.
- W2002128807 cites W2032718183 @default.
- W2002128807 cites W2045989044 @default.
- W2002128807 cites W2047144629 @default.
- W2002128807 cites W2052898293 @default.
- W2002128807 cites W2057783377 @default.
- W2002128807 cites W2058148599 @default.
- W2002128807 cites W2061860574 @default.
- W2002128807 cites W2064476272 @default.
- W2002128807 cites W2080555638 @default.
- W2002128807 cites W2092764529 @default.
- W2002128807 cites W2095103695 @default.
- W2002128807 cites W2102083512 @default.
- W2002128807 cites W2103861118 @default.
- W2002128807 cites W2104834094 @default.
- W2002128807 cites W2134079957 @default.
- W2002128807 cites W2152663903 @default.
- W2002128807 cites W2154948430 @default.
- W2002128807 cites W4231710253 @default.
- W2002128807 cites W4251605594 @default.
- W2002128807 cites W4255276575 @default.
- W2002128807 doi "https://doi.org/10.1016/0197-4580(93)90030-f" @default.
- W2002128807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8095700" @default.
- W2002128807 hasPublicationYear "1993" @default.
- W2002128807 type Work @default.
- W2002128807 sameAs 2002128807 @default.
- W2002128807 citedByCount "72" @default.
- W2002128807 countsByYear W20021288072012 @default.
- W2002128807 countsByYear W20021288072013 @default.
- W2002128807 countsByYear W20021288072015 @default.
- W2002128807 countsByYear W20021288072019 @default.
- W2002128807 countsByYear W20021288072020 @default.
- W2002128807 countsByYear W20021288072021 @default.
- W2002128807 crossrefType "journal-article" @default.
- W2002128807 hasAuthorship W2002128807A5039247811 @default.
- W2002128807 hasAuthorship W2002128807A5042422785 @default.
- W2002128807 hasAuthorship W2002128807A5070236497 @default.
- W2002128807 hasAuthorship W2002128807A5079424184 @default.
- W2002128807 hasConcept C126322002 @default.
- W2002128807 hasConcept C134018914 @default.
- W2002128807 hasConcept C148762608 @default.
- W2002128807 hasConcept C15744967 @default.
- W2002128807 hasConcept C169760540 @default.
- W2002128807 hasConcept C170493617 @default.
- W2002128807 hasConcept C185263204 @default.
- W2002128807 hasConcept C185592680 @default.
- W2002128807 hasConcept C25876315 @default.
- W2002128807 hasConcept C2776219046 @default.
- W2002128807 hasConcept C2777222312 @default.
- W2002128807 hasConcept C2781123555 @default.
- W2002128807 hasConcept C2781161787 @default.
- W2002128807 hasConcept C2781423529 @default.
- W2002128807 hasConcept C529278444 @default.
- W2002128807 hasConcept C61174792 @default.
- W2002128807 hasConcept C67018056 @default.
- W2002128807 hasConcept C71924100 @default.
- W2002128807 hasConcept C86803240 @default.
- W2002128807 hasConceptScore W2002128807C126322002 @default.
- W2002128807 hasConceptScore W2002128807C134018914 @default.
- W2002128807 hasConceptScore W2002128807C148762608 @default.
- W2002128807 hasConceptScore W2002128807C15744967 @default.