Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002129635> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2002129635 endingPage "40" @default.
- W2002129635 startingPage "34" @default.
- W2002129635 abstract "The question of how cysteinyl-tRNA(Cys) is synthesized in organisms that lack a canonical cysteinyl-tRNA synthetase (CysRS) is an important open question in understanding protein synthesis. The prolyl-tRNA synthetase (ProRS) of wide ranging organisms has the ability to mis-activate cysteine without editing. This raises the question of whether the mis-activated cysteine can be charged to tRNA(Cys) to synthesize the correctly matched cys-tRNA(Cys), which may serve as an option in organisms that lack the conventional CysRS. Despite intense searches, such an activity has not been found. Here we show that the ProRS of the radiation-resistant bacterium Deinococcus radiodurans has the ability to charge cysteine to tRNA(Cys) and to retain the cognate pair cys-tRNA(Cys) stably without editing. The cysteinylation by D. radiodurans ProRS is not the major route for synthesis of cys-tRNA(Cys), however, because the organism encodes the conventional CysRS. Nonetheless, the synthesis of cys-tRNA(Cys) in vitro is important and it is unlike previously documented mis-charging of Methanocaldococcus jannaschii ProRS, which synthesizes cys-tRNA(Pro) but not cys-tRNA(Cys). We suggest that the cysteinylation activity of D. radiodruans ProRS may, in the presence of additional factors, offer one option to organisms that lack the conventional CysRS to synthesize cysteinyl-tRNA(Cys) in vivo." @default.
- W2002129635 created "2016-06-24" @default.
- W2002129635 creator A5063729716 @default.
- W2002129635 creator A5089964310 @default.
- W2002129635 date "2004-05-01" @default.
- W2002129635 modified "2023-09-27" @default.
- W2002129635 title "Synthesis of Cysteinyl-tRNACys by A Prolyl-tRNA Synthetase" @default.
- W2002129635 doi "https://doi.org/10.4161/rna.1.1.910" @default.
- W2002129635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17194940" @default.
- W2002129635 hasPublicationYear "2004" @default.
- W2002129635 type Work @default.
- W2002129635 sameAs 2002129635 @default.
- W2002129635 citedByCount "3" @default.
- W2002129635 countsByYear W20021296352014 @default.
- W2002129635 countsByYear W20021296352016 @default.
- W2002129635 crossrefType "journal-article" @default.
- W2002129635 hasAuthorship W2002129635A5063729716 @default.
- W2002129635 hasAuthorship W2002129635A5089964310 @default.
- W2002129635 hasBestOaLocation W20021296351 @default.
- W2002129635 hasConcept C104317684 @default.
- W2002129635 hasConcept C153957851 @default.
- W2002129635 hasConcept C181199279 @default.
- W2002129635 hasConcept C2776519032 @default.
- W2002129635 hasConcept C2779201268 @default.
- W2002129635 hasConcept C2779315393 @default.
- W2002129635 hasConcept C3675279 @default.
- W2002129635 hasConcept C515207424 @default.
- W2002129635 hasConcept C552990157 @default.
- W2002129635 hasConcept C55493867 @default.
- W2002129635 hasConcept C67705224 @default.
- W2002129635 hasConcept C86803240 @default.
- W2002129635 hasConceptScore W2002129635C104317684 @default.
- W2002129635 hasConceptScore W2002129635C153957851 @default.
- W2002129635 hasConceptScore W2002129635C181199279 @default.
- W2002129635 hasConceptScore W2002129635C2776519032 @default.
- W2002129635 hasConceptScore W2002129635C2779201268 @default.
- W2002129635 hasConceptScore W2002129635C2779315393 @default.
- W2002129635 hasConceptScore W2002129635C3675279 @default.
- W2002129635 hasConceptScore W2002129635C515207424 @default.
- W2002129635 hasConceptScore W2002129635C552990157 @default.
- W2002129635 hasConceptScore W2002129635C55493867 @default.
- W2002129635 hasConceptScore W2002129635C67705224 @default.
- W2002129635 hasConceptScore W2002129635C86803240 @default.
- W2002129635 hasIssue "1" @default.
- W2002129635 hasLocation W20021296351 @default.
- W2002129635 hasLocation W20021296352 @default.
- W2002129635 hasOpenAccess W2002129635 @default.
- W2002129635 hasPrimaryLocation W20021296351 @default.
- W2002129635 hasRelatedWork W1553079870 @default.
- W2002129635 hasRelatedWork W1978858109 @default.
- W2002129635 hasRelatedWork W1986692037 @default.
- W2002129635 hasRelatedWork W1987122174 @default.
- W2002129635 hasRelatedWork W2002129635 @default.
- W2002129635 hasRelatedWork W2009941107 @default.
- W2002129635 hasRelatedWork W2034202145 @default.
- W2002129635 hasRelatedWork W2053445012 @default.
- W2002129635 hasRelatedWork W2063340676 @default.
- W2002129635 hasRelatedWork W2077451740 @default.
- W2002129635 hasVolume "1" @default.
- W2002129635 isParatext "false" @default.
- W2002129635 isRetracted "false" @default.
- W2002129635 magId "2002129635" @default.
- W2002129635 workType "article" @default.