Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002129908> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2002129908 endingPage "327" @default.
- W2002129908 startingPage "322" @default.
- W2002129908 abstract "The disposition of chlorproguanil/dapsone (one daily dose for 3 d of 1·2 and 2·4 mg/kg respectively) has been studied in young children with Plasmodium falciparum malaria, to provide data complementary to a clinical trial of this drug combination. Unbound concentrations of chlorcycloguanil (the active metabolite of chlorproguanil) and dapsone in clinical samples have been related to the unbound drug concentrations which produced defined outcomes in tests in vitro of drug efficacy and toxicity. Twelve children with uncomplicated malaria were treated: all cleared parasitaemia within 72 h and made uneventful recoveries. After the first dose of chlorproguanil/dapsone the maximum unbound chlorcycloguanil concentration in clinical samples (19 ng/mL [about 60 nM]) was 2 orders of magnitude above the 50% inhibitory concentration (IC50) value for this drug against the K39 strain of P falciparum, while falling 2 orders of magnitude below its IC50 against human bone marrow cells; the maximum unbound dapsone concentration in clinical samples (160 ng/mL [about 645 nM]) was 10-fold higher than its IC50 against the K39 strain. However, because of the rapid elimination of chlorproguanil from the body (half-life 12·6 ± 6·3 h), the minimum fractional inhibitory concentrations of unbound chlorcycloguanil/dapsone against the K39 strain were probably exceeded for no more than 6 d. These data, together with the clinical trial, will be helpful in deciding whether current chlorproguanil/dapsone doses are optimal for the treatment of falciparum malaria." @default.
- W2002129908 created "2016-06-24" @default.
- W2002129908 creator A5018692963 @default.
- W2002129908 creator A5019623012 @default.
- W2002129908 creator A5022372798 @default.
- W2002129908 creator A5047855786 @default.
- W2002129908 creator A5061408949 @default.
- W2002129908 creator A5072332085 @default.
- W2002129908 date "1997-05-01" @default.
- W2002129908 modified "2023-09-23" @default.
- W2002129908 title "Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic range" @default.
- W2002129908 cites W1901110847 @default.
- W2002129908 cites W1963693714 @default.
- W2002129908 cites W1964268338 @default.
- W2002129908 cites W1968925349 @default.
- W2002129908 cites W1971729111 @default.
- W2002129908 cites W1976217151 @default.
- W2002129908 cites W1998585498 @default.
- W2002129908 cites W2006005525 @default.
- W2002129908 cites W2012429505 @default.
- W2002129908 cites W2017351843 @default.
- W2002129908 cites W2059838568 @default.
- W2002129908 cites W2061261695 @default.
- W2002129908 cites W2068125083 @default.
- W2002129908 cites W2069315040 @default.
- W2002129908 cites W2073192813 @default.
- W2002129908 cites W2088401407 @default.
- W2002129908 cites W2094805343 @default.
- W2002129908 cites W2098074409 @default.
- W2002129908 cites W2116717899 @default.
- W2002129908 cites W2154294557 @default.
- W2002129908 cites W2163515971 @default.
- W2002129908 doi "https://doi.org/10.1016/s0035-9203(97)90093-6" @default.
- W2002129908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9231209" @default.
- W2002129908 hasPublicationYear "1997" @default.
- W2002129908 type Work @default.
- W2002129908 sameAs 2002129908 @default.
- W2002129908 citedByCount "66" @default.
- W2002129908 countsByYear W20021299082012 @default.
- W2002129908 countsByYear W20021299082014 @default.
- W2002129908 countsByYear W20021299082015 @default.
- W2002129908 countsByYear W20021299082020 @default.
- W2002129908 crossrefType "journal-article" @default.
- W2002129908 hasAuthorship W2002129908A5018692963 @default.
- W2002129908 hasAuthorship W2002129908A5019623012 @default.
- W2002129908 hasAuthorship W2002129908A5022372798 @default.
- W2002129908 hasAuthorship W2002129908A5047855786 @default.
- W2002129908 hasAuthorship W2002129908A5061408949 @default.
- W2002129908 hasAuthorship W2002129908A5072332085 @default.
- W2002129908 hasConcept C112705442 @default.
- W2002129908 hasConcept C126322002 @default.
- W2002129908 hasConcept C185592680 @default.
- W2002129908 hasConcept C202751555 @default.
- W2002129908 hasConcept C203014093 @default.
- W2002129908 hasConcept C2777477808 @default.
- W2002129908 hasConcept C2777640609 @default.
- W2002129908 hasConcept C2777752497 @default.
- W2002129908 hasConcept C2778048844 @default.
- W2002129908 hasConcept C2778371730 @default.
- W2002129908 hasConcept C2780035454 @default.
- W2002129908 hasConcept C55493867 @default.
- W2002129908 hasConcept C71924100 @default.
- W2002129908 hasConcept C98274493 @default.
- W2002129908 hasConceptScore W2002129908C112705442 @default.
- W2002129908 hasConceptScore W2002129908C126322002 @default.
- W2002129908 hasConceptScore W2002129908C185592680 @default.
- W2002129908 hasConceptScore W2002129908C202751555 @default.
- W2002129908 hasConceptScore W2002129908C203014093 @default.
- W2002129908 hasConceptScore W2002129908C2777477808 @default.
- W2002129908 hasConceptScore W2002129908C2777640609 @default.
- W2002129908 hasConceptScore W2002129908C2777752497 @default.
- W2002129908 hasConceptScore W2002129908C2778048844 @default.
- W2002129908 hasConceptScore W2002129908C2778371730 @default.
- W2002129908 hasConceptScore W2002129908C2780035454 @default.
- W2002129908 hasConceptScore W2002129908C55493867 @default.
- W2002129908 hasConceptScore W2002129908C71924100 @default.
- W2002129908 hasConceptScore W2002129908C98274493 @default.
- W2002129908 hasIssue "3" @default.
- W2002129908 hasLocation W20021299081 @default.
- W2002129908 hasLocation W20021299082 @default.
- W2002129908 hasOpenAccess W2002129908 @default.
- W2002129908 hasPrimaryLocation W20021299081 @default.
- W2002129908 hasRelatedWork W1492229869 @default.
- W2002129908 hasRelatedWork W1903390813 @default.
- W2002129908 hasRelatedWork W1964759623 @default.
- W2002129908 hasRelatedWork W1969876219 @default.
- W2002129908 hasRelatedWork W1998356222 @default.
- W2002129908 hasRelatedWork W2049819497 @default.
- W2002129908 hasRelatedWork W2056938528 @default.
- W2002129908 hasRelatedWork W2132691174 @default.
- W2002129908 hasRelatedWork W2400461952 @default.
- W2002129908 hasRelatedWork W4205993769 @default.
- W2002129908 hasVolume "91" @default.
- W2002129908 isParatext "false" @default.
- W2002129908 isRetracted "false" @default.
- W2002129908 magId "2002129908" @default.
- W2002129908 workType "article" @default.