FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002130197> ?p ?o ?g. }

• W2002130197 endingPage "71" @default.
• W2002130197 startingPage "61" @default.
• W2002130197 abstract "The interaction of chronic in vivo lead exposure and acute in vitro ethanol treatment on synaptic neurotransmission and plasticity were studied using extracellular electrophysiological techniques in CA1 region of hippocampal brain slices from adult rats. Neither chronic lead exposure nor acute ethanol treatment had any significant effect on field excitatory postsynaptic potentials (EPSPs). In vivo lead exposure enhanced short-term potentiation (STP, potentiation that decays within 30 min) by 21% shortly after 'weak' tetanus, but had no effect on long-term potentiation (LTP, sustained at least 1 h). In vitro bath application of 60 mM ethanol inhibited STP by 35% and blocked LTP induced by 'weak' tetanus in slices from Pb exposed rats (500 ppm lead acetate, 56-70 days), while having no effect on STP or LTP in slices from control counterpart Na-exposed rats (pair-fed 216 ppm sodium acetate). In contrast, 'strong'-tetanus-induced LTP was abolished in Pb-exposed slices, and 60 mM ethanol slightly inhibited STP and blocked LTP in slices from Na-exposed rats. These differences could not be explained by differences in ethanol inhibition of NMDA-mediated field EPSPs because they were similarly reduced in slices from Na-exposed (30%) and Pb-exposed (25%) rats. These findings suggest that the strength of the tetanus used determines whether or not synaptic plasticity is blocked by either chronic lead exposure or acute ethanol treatment, and that even in adult rats, hippocampal synaptic LTP can be compromised by combined exposure to ethanol and lead. More importantly, these findings suggest the consequences of combined lead exposure and alcohol abuse in the adult human population may not be fully recognized yet." @default.
• W2002130197 created "2016-06-24" @default.
• W2002130197 creator A5063384572 @default.
• W2002130197 creator A5083063565 @default.
• W2002130197 date "1996-09-23" @default.
• W2002130197 modified "2023-10-17" @default.
• W2002130197 title "Ethanol effects on synaptic neurotransmission and tetanus-induced synaptic plasticity in hippocampal slices of chronic in vivo lead-exposed adult rats." @default.
• W2002130197 cites W135855325 @default.
• W2002130197 cites W1555529117 @default.
• W2002130197 cites W1814728846 @default.
• W2002130197 cites W1964671285 @default.
• W2002130197 cites W1964903941 @default.
• W2002130197 cites W1966167674 @default.
• W2002130197 cites W1970283692 @default.
• W2002130197 cites W1970584427 @default.
• W2002130197 cites W1976036739 @default.
• W2002130197 cites W1976814688 @default.
• W2002130197 cites W1978249390 @default.
• W2002130197 cites W1988518642 @default.
• W2002130197 cites W1989594914 @default.
• W2002130197 cites W1992308207 @default.
• W2002130197 cites W1997859029 @default.
• W2002130197 cites W1998603233 @default.
• W2002130197 cites W1999612514 @default.
• W2002130197 cites W2003953294 @default.
• W2002130197 cites W2008920735 @default.
• W2002130197 cites W2009988664 @default.
• W2002130197 cites W2019496735 @default.
• W2002130197 cites W2021289026 @default.
• W2002130197 cites W2022826973 @default.
• W2002130197 cites W2024595782 @default.
• W2002130197 cites W2028637704 @default.
• W2002130197 cites W2029793858 @default.
• W2002130197 cites W2029853771 @default.
• W2002130197 cites W2033025054 @default.
• W2002130197 cites W2033329010 @default.
• W2002130197 cites W2042954027 @default.
• W2002130197 cites W2044253923 @default.
• W2002130197 cites W2048601301 @default.
• W2002130197 cites W2049511526 @default.
• W2002130197 cites W2049680037 @default.
• W2002130197 cites W2051069074 @default.
• W2002130197 cites W2056529371 @default.
• W2002130197 cites W2059089847 @default.
• W2002130197 cites W2059767644 @default.
• W2002130197 cites W2059916871 @default.
• W2002130197 cites W2073537077 @default.
• W2002130197 cites W2074581377 @default.
• W2002130197 cites W2076125076 @default.
• W2002130197 cites W2076937222 @default.
• W2002130197 cites W2092678699 @default.
• W2002130197 cites W2113991700 @default.
• W2002130197 cites W2134232707 @default.
• W2002130197 cites W2150988578 @default.
• W2002130197 cites W2189611103 @default.
• W2002130197 cites W2253667286 @default.
• W2002130197 cites W2338715367 @default.
• W2002130197 cites W23773397 @default.
• W2002130197 cites W2411753646 @default.
• W2002130197 cites W2438786899 @default.
• W2002130197 cites W2439758457 @default.
• W2002130197 cites W3021526609 @default.
• W2002130197 cites W3159014016 @default.
• W2002130197 cites W34054923 @default.
• W2002130197 cites W642519521 @default.
• W2002130197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8896809" @default.
• W2002130197 hasPublicationYear "1996" @default.
• W2002130197 type Work @default.
• W2002130197 sameAs 2002130197 @default.
• W2002130197 citedByCount "6" @default.
• W2002130197 countsByYear W20021301972013 @default.
• W2002130197 countsByYear W20021301972015 @default.
• W2002130197 crossrefType "journal-article" @default.
• W2002130197 hasAuthorship W2002130197A5063384572 @default.
• W2002130197 hasAuthorship W2002130197A5083063565 @default.
• W2002130197 hasConcept C112592302 @default.
• W2002130197 hasConcept C126322002 @default.
• W2002130197 hasConcept C134018914 @default.
• W2002130197 hasConcept C148762608 @default.
• W2002130197 hasConcept C150903083 @default.
• W2002130197 hasConcept C170493617 @default.
• W2002130197 hasConcept C17077164 @default.
• W2002130197 hasConcept C178790620 @default.
• W2002130197 hasConcept C185592680 @default.
• W2002130197 hasConcept C197341189 @default.
• W2002130197 hasConcept C200170125 @default.
• W2002130197 hasConcept C207001950 @default.
• W2002130197 hasConcept C25274449 @default.
• W2002130197 hasConcept C2779224224 @default.
• W2002130197 hasConcept C2780161600 @default.
• W2002130197 hasConcept C29730261 @default.
• W2002130197 hasConcept C55493867 @default.
• W2002130197 hasConcept C67018056 @default.
• W2002130197 hasConcept C71924100 @default.
• W2002130197 hasConcept C86803240 @default.
• W2002130197 hasConcept C98229152 @default.
• W2002130197 hasConceptScore W2002130197C112592302 @default.
• W2002130197 hasConceptScore W2002130197C126322002 @default.

• next