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- W2002132074 abstract "Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+ +/- Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 microM S-100 is half-saturated by 0.18 microM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 microM CPZ in the presence of Mg2+ plus EGTA. The extent of the binding is greater in the presence of Ca2+ than in the presence of EGTA, especially at low CPZ concentrations." @default.
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- W2002132074 title "Binding of Chlorpromazine to S-100 Protein" @default.
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- W2002132074 doi "https://doi.org/10.1111/j.1471-4159.1984.tb02811.x" @default.
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