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- W2002133417 abstract "This paper focuses on the interaction between oxidized hemoglobin and the erythrocyte membrane, and its relevance to some falciparum malaria-linked genetic traits. We first present the experimental evidence which suggests that the interaction between hemoglobin derivatives and membrane proteins is an important cellular mechanism for the erythrocytes carrying HbS, HbE, HbF, α- and β-thalassemia, and G6PD deficiency. Thereafter, we show how the Hb/membrane interaction might act as primum movens for diverse cellular mechanisms which 1) reduce invasion of erythrocytes by the falciparum parasite; 2) impair parasite survival and development within the cell; 3) accelerate infected erythrocyte clearance by phagocytosis. We claim that oxidative stress is the driving force of this process, since highly reactive species (like O2− and H2O2) mediate the gradual oxidation of Hb to irreversible hemichrome-containing Heinz bodies. We therefore suggest that positing the interaction between oxidized hemoglobin and cell membrane as a common basis for several falciparum malaria-linked genetic traits is not only consistent with experimental evidence gathered so far, but provides a new, clearer perspective: the molecular event on which these known protective traits rest. In the last part of the paper we will discuss two case studies which provide further support for the role played by hemoglobin derivatives and membrane proteins: 1) the influence of a cyanogen-rich diet on the distribution of Hbβ*S gene frequencies in Liberia (Jackson [1990] Am. J. Hum. Biol. 2:521–532); and 2) population data on polymorphisms at the Hbβ and GPXI loci (Destro-Bisol and Spedini [1989] Am. J. Phys. Anthropol. 79:217–224). © 1996 Wiley-Liss, Inc." @default.
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- W2002133417 date "1996-01-01" @default.
- W2002133417 modified "2023-09-25" @default.
- W2002133417 title "Interaction between oxidized hemoglobin and the cell membrane: A common basis for severalfalciparum malaria-linked genetic traits" @default.
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