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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002136337> ?p ?o ?g. }

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• W2002136337 abstract "Abstract The eukaryotic initiation factor eIF4E is essential for cap-dependent initiation of translation in eukaryotes. Abnormal regulation of eIF4E has been implicated in oncogenic transformation. We developed an eIF4E-binding peptide derived from Angel1, a partner of eIF4E that we recently identified. We show here that this peptide fused to a penetratin motif causes drastic and rapid cell death in several epithelial cancer cell lines. This necrotic cell death was characterized by a drop in ATP levels with F-actin network injury being a key step in extensive plasma membrane blebbing and membrane permeabilization. This synthetic eIF4E-binding peptide provides a candidate pharmacophore for a promising new cancer therapy strategy." @default.
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• W2002136337 date "2014-10-30" @default.
• W2002136337 modified "2023-10-11" @default.
• W2002136337 title "An eIF4E-interacting peptide induces cell death in cancer cell lines" @default.
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• W2002136337 doi "https://doi.org/10.1038/cddis.2014.457" @default.
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