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• W2002139436 abstract "Skeletal muscle biopsies were taken from 43 cancer patients and 55 matched, presumably metabolically healthy controls for determinations of enzyme activities, capacity of glucose assimilation and metabolism and the incorporation rate of leucine into proteins. In muscle tissue from cancer patients the activities of the lysosomal enzymes, cathepsin-D and β-glucuronidase, were increased. Acid phosphatase activity was the same as in muscle tissue from the controls. The activities of hexokinase, phosphofructokinase, lactate dehydrogenase, and cytochrome-c-oxidase were significantly decreased. This decrease was accompanied by a decreased incorporation rate of glucose-carbon into glycogen, lactate and CO2. The incorporation rate of leucine into proteins was significantly decreased in cancer patients and the fractional degradation rate of proteins was increased. Amino acids caused the same degree of stimulation on the leucine incorporation rate into proteins as in the controls. The RNA concentration was unchanged in muscles from the cancer patients. The results suggest that malignant tumors provoke specific alterations of the skeletal muscle metabolism of the host. The rate of protein biosynthesis seems to be decreased together with an increased degradation rate. The capacity for glucose assimilation and metabolism is decreased indicating a disturbed energy regulation in the muscles of cancer patients." @default.
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• W2002139436 date "1976-06-01" @default.
• W2002139436 modified "2023-09-30" @default.
• W2002139436 title "Skeletal muscle metabolism in patients with malignant tumor" @default.
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• W2002139436 doi "https://doi.org/10.1016/0014-2964(76)90036-0" @default.
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