Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002139512> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2002139512 endingPage "1082" @default.
- W2002139512 startingPage "1079" @default.
- W2002139512 abstract "Abstract: Presynaptic correlates of evoked neurotransmitter release include a rise in cytosolic free calcium level and the calcium-dependent liberation of unesterified arachidonic acid. It has been proposed that lipoxygenase metabolites produced from arachidonic acid may constitute an endogenous feedback system for the modulation of neurotransmitter release. The results of the present study are in agreement with this hypothesis. It was demonstrated that membrane depolarization evoked the release of endogenous glutamate from hippocampal mossy fiber synaptosomes, as well as the accumulation of intraterminal free calcium. The presence of 12-lipoxygenase products attenuated both the induced release of glutamate and the increase in calcium content, whereas 5- or 15-lipoxygenase metabolites were ineffective. A role for lipoxygenase products in the negative modulation of mossy fiber secretion processes was further indicated by the observations that low concentrations of the lipoxygenase inhibitor nordihydroguaiaretic acid (0.1–10 μM) potentiated the glutamate release and calcium accumulation induced by membrane depolarization. Therefore, we suggest that 12-lipoxygenase metabolites provide a presynaptic inhibitory signal that limits neurotransmitter release from hippocampal mossy fiber terminals." @default.
- W2002139512 created "2016-06-24" @default.
- W2002139512 creator A5016534328 @default.
- W2002139512 creator A5037530353 @default.
- W2002139512 creator A5043529612 @default.
- W2002139512 creator A5044196607 @default.
- W2002139512 date "1991-03-01" @default.
- W2002139512 modified "2023-09-23" @default.
- W2002139512 title "12-Lipoxygenase Products Attenuate the Glutamate Release and Ca<sup>2+</sup>Accumulation Evoked by Depolarization of Hippocampal Mossy Fiber Nerve Endings" @default.
- W2002139512 cites W1491645708 @default.
- W2002139512 cites W1964901085 @default.
- W2002139512 cites W1989501276 @default.
- W2002139512 cites W1992594183 @default.
- W2002139512 cites W2006817544 @default.
- W2002139512 cites W2018773586 @default.
- W2002139512 cites W2039531779 @default.
- W2002139512 cites W2047215721 @default.
- W2002139512 cites W2060203976 @default.
- W2002139512 cites W2062748636 @default.
- W2002139512 cites W2075462723 @default.
- W2002139512 cites W2081702080 @default.
- W2002139512 cites W2088618017 @default.
- W2002139512 cites W2095355752 @default.
- W2002139512 cites W2141260882 @default.
- W2002139512 doi "https://doi.org/10.1111/j.1471-4159.1991.tb02032.x" @default.
- W2002139512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1671585" @default.
- W2002139512 hasPublicationYear "1991" @default.
- W2002139512 type Work @default.
- W2002139512 sameAs 2002139512 @default.
- W2002139512 citedByCount "37" @default.
- W2002139512 countsByYear W20021395122015 @default.
- W2002139512 crossrefType "journal-article" @default.
- W2002139512 hasAuthorship W2002139512A5016534328 @default.
- W2002139512 hasAuthorship W2002139512A5037530353 @default.
- W2002139512 hasAuthorship W2002139512A5043529612 @default.
- W2002139512 hasAuthorship W2002139512A5044196607 @default.
- W2002139512 hasConcept C12554922 @default.
- W2002139512 hasConcept C148762608 @default.
- W2002139512 hasConcept C169760540 @default.
- W2002139512 hasConcept C170493617 @default.
- W2002139512 hasConcept C178790620 @default.
- W2002139512 hasConcept C181199279 @default.
- W2002139512 hasConcept C185592680 @default.
- W2002139512 hasConcept C2776219046 @default.
- W2002139512 hasConcept C2776464000 @default.
- W2002139512 hasConcept C2777318268 @default.
- W2002139512 hasConcept C2778078955 @default.
- W2002139512 hasConcept C2778921374 @default.
- W2002139512 hasConcept C4141045 @default.
- W2002139512 hasConcept C41625074 @default.
- W2002139512 hasConcept C519063684 @default.
- W2002139512 hasConcept C55493867 @default.
- W2002139512 hasConcept C61174792 @default.
- W2002139512 hasConcept C86803240 @default.
- W2002139512 hasConceptScore W2002139512C12554922 @default.
- W2002139512 hasConceptScore W2002139512C148762608 @default.
- W2002139512 hasConceptScore W2002139512C169760540 @default.
- W2002139512 hasConceptScore W2002139512C170493617 @default.
- W2002139512 hasConceptScore W2002139512C178790620 @default.
- W2002139512 hasConceptScore W2002139512C181199279 @default.
- W2002139512 hasConceptScore W2002139512C185592680 @default.
- W2002139512 hasConceptScore W2002139512C2776219046 @default.
- W2002139512 hasConceptScore W2002139512C2776464000 @default.
- W2002139512 hasConceptScore W2002139512C2777318268 @default.
- W2002139512 hasConceptScore W2002139512C2778078955 @default.
- W2002139512 hasConceptScore W2002139512C2778921374 @default.
- W2002139512 hasConceptScore W2002139512C4141045 @default.
- W2002139512 hasConceptScore W2002139512C41625074 @default.
- W2002139512 hasConceptScore W2002139512C519063684 @default.
- W2002139512 hasConceptScore W2002139512C55493867 @default.
- W2002139512 hasConceptScore W2002139512C61174792 @default.
- W2002139512 hasConceptScore W2002139512C86803240 @default.
- W2002139512 hasIssue "3" @default.
- W2002139512 hasLocation W20021395121 @default.
- W2002139512 hasLocation W20021395122 @default.
- W2002139512 hasOpenAccess W2002139512 @default.
- W2002139512 hasPrimaryLocation W20021395121 @default.
- W2002139512 hasRelatedWork W2001914791 @default.
- W2002139512 hasRelatedWork W2014742403 @default.
- W2002139512 hasRelatedWork W2024893386 @default.
- W2002139512 hasRelatedWork W2037049389 @default.
- W2002139512 hasRelatedWork W2041383136 @default.
- W2002139512 hasRelatedWork W2042030103 @default.
- W2002139512 hasRelatedWork W2144487536 @default.
- W2002139512 hasRelatedWork W2338911760 @default.
- W2002139512 hasRelatedWork W2401640372 @default.
- W2002139512 hasRelatedWork W2086410419 @default.
- W2002139512 hasVolume "56" @default.
- W2002139512 isParatext "false" @default.
- W2002139512 isRetracted "false" @default.
- W2002139512 magId "2002139512" @default.
- W2002139512 workType "article" @default.