FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002141750> ?p ?o ?g. }

• W2002141750 endingPage "1217" @default.
• W2002141750 startingPage "1200" @default.
• W2002141750 abstract "Diagnostics and rehabilitation of Parkinson’s disease (PD) presents the current information pertaining to etiology, early biomarkers for diagnostics, novel methods to evaluate symptoms, multidisciplinary rehabilitation, new applications of brain imaging and invasive methods to the study of PD. Researchers have only recently begun to focus on the non-motor symptoms of PD, which are poorly recognized and inadequately treated by clinicians. The non-motor symptoms of PD have a significant impact on patient quality of life and mortality, and include cognitive impairments, autonomic, gastrointestinal, and sensory symptoms. Indepth discussion of the use of imaging tools to study disease mechanisms is also provided, with emphasis on the abnormal network organization in parkinsonism. Deep brain stimulation management is a paradigm-shifting therapy for PD, essential tremor and dystonia. In the recent years, new approaches of early diagnostics, training programmes and treatments have vastly improved the lives of people with PD, substantially reducing symptoms and significantly delaying disability. PD results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction and oxidative stress, may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cas-cade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process." @default.
• W2002141750 created "2016-06-24" @default.
• W2002141750 creator A5027442138 @default.
• W2002141750 date "2012-01-01" @default.
• W2002141750 modified "2023-09-30" @default.
• W2002141750 title "Diagnostics, rehabilitation and models of Parkinson’s disease" @default.
• W2002141750 cites W106303051 @default.
• W2002141750 cites W1499097287 @default.
• W2002141750 cites W1569322902 @default.
• W2002141750 cites W1605741293 @default.
• W2002141750 cites W1607667183 @default.
• W2002141750 cites W1822874530 @default.
• W2002141750 cites W1897746339 @default.
• W2002141750 cites W1963543321 @default.
• W2002141750 cites W1964243396 @default.
• W2002141750 cites W1964491268 @default.
• W2002141750 cites W1964554773 @default.
• W2002141750 cites W1964888200 @default.
• W2002141750 cites W1965860594 @default.
• W2002141750 cites W1966048928 @default.
• W2002141750 cites W1967070205 @default.
• W2002141750 cites W1967895933 @default.
• W2002141750 cites W1970032686 @default.
• W2002141750 cites W1971676543 @default.
• W2002141750 cites W1972638339 @default.
• W2002141750 cites W1973160597 @default.
• W2002141750 cites W1973698406 @default.
• W2002141750 cites W1974311807 @default.
• W2002141750 cites W1975308400 @default.
• W2002141750 cites W1975727839 @default.
• W2002141750 cites W1975870239 @default.
• W2002141750 cites W1976645698 @default.
• W2002141750 cites W1978576968 @default.
• W2002141750 cites W1978936911 @default.
• W2002141750 cites W1979157312 @default.
• W2002141750 cites W1979915908 @default.
• W2002141750 cites W1980225167 @default.
• W2002141750 cites W1980255458 @default.
• W2002141750 cites W1981005146 @default.
• W2002141750 cites W1981628434 @default.
• W2002141750 cites W1983627905 @default.
• W2002141750 cites W1988003374 @default.
• W2002141750 cites W1989221987 @default.
• W2002141750 cites W1989893146 @default.
• W2002141750 cites W1990057632 @default.
• W2002141750 cites W1990287702 @default.
• W2002141750 cites W1991951696 @default.
• W2002141750 cites W1992328286 @default.
• W2002141750 cites W1992483894 @default.
• W2002141750 cites W1992566452 @default.
• W2002141750 cites W1992729377 @default.
• W2002141750 cites W1994381645 @default.
• W2002141750 cites W1994814194 @default.
• W2002141750 cites W1996376005 @default.
• W2002141750 cites W1996689106 @default.
• W2002141750 cites W1999792210 @default.
• W2002141750 cites W2002373649 @default.
• W2002141750 cites W2003938093 @default.
• W2002141750 cites W2005508231 @default.
• W2002141750 cites W2006199542 @default.
• W2002141750 cites W2009485026 @default.
• W2002141750 cites W2010616761 @default.
• W2002141750 cites W2012171546 @default.
• W2002141750 cites W2012567998 @default.
• W2002141750 cites W2014143845 @default.
• W2002141750 cites W2015115289 @default.
• W2002141750 cites W2015932693 @default.
• W2002141750 cites W2016185936 @default.
• W2002141750 cites W2019977359 @default.
• W2002141750 cites W2021198310 @default.
• W2002141750 cites W2021555709 @default.
• W2002141750 cites W2021735407 @default.
• W2002141750 cites W2022049348 @default.
• W2002141750 cites W2022893981 @default.
• W2002141750 cites W2025026150 @default.
• W2002141750 cites W2026455995 @default.
• W2002141750 cites W2026497992 @default.
• W2002141750 cites W2027676764 @default.
• W2002141750 cites W2027958854 @default.
• W2002141750 cites W2028171714 @default.
• W2002141750 cites W2029284138 @default.
• W2002141750 cites W2029873665 @default.
• W2002141750 cites W2030012686 @default.
• W2002141750 cites W2031439839 @default.
• W2002141750 cites W2031895693 @default.
• W2002141750 cites W2032621752 @default.
• W2002141750 cites W2034161115 @default.
• W2002141750 cites W2034919415 @default.
• W2002141750 cites W2036981601 @default.
• W2002141750 cites W2039002297 @default.
• W2002141750 cites W2039405296 @default.
• W2002141750 cites W2041185808 @default.
• W2002141750 cites W2042890237 @default.
• W2002141750 cites W2043448977 @default.
• W2002141750 cites W2045402408 @default.
• W2002141750 cites W2046654564 @default.
• W2002141750 cites W2047853787 @default.
• W2002141750 cites W2049078874 @default.

• next