Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002142711> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2002142711 endingPage "12" @default.
- W2002142711 startingPage "1" @default.
- W2002142711 abstract "1. Five presynaptic toxins have been isolated in pure from from the venom of Bungarus multicinctus and Bungarus caeruleus and named β1, β2, β3, β4, and β-ceruleotoxin. 2. They differ in electrophoretic mobility and amino acid composition, while all have the same molecular weight (22000) and are composed of two subunits of molecular weight 9000 and 12000. 3. The toxins have phospholipase A activity when assayed with both natural and synthetic phospholipids, and this activity requires the presence of Ca2+ ions. 4. β-Bungarotoxin (β3) binds 1 mol of Ca2+ per mol of protein and this binding induces a conformational change as detected by fluorescence measurements in the presence of the dye 8-anilino-1-naphthalene sulfonic acid. 5. The phospholipase activity of all the toxins is lost when a critical histidine residue is modified with p-bromophenancyl bromide. 6. As a result of the modification the lethality of the toxins is greatly reduced. 7. Native toxin causes a rapid decrease in amplitude of end-plate potentials, followed by a transient increase and subsequent decrease, until transmitter release is completely abolished. The modified toxin still causes the early decrease in release but toxin action does not progress to complete block. 8. The rate of blockage of transmitter release by native toxin is reduced in the presence of modified toxin. 9. It is concluded that phospholipase activity plays an important role in the action of this class of toxins at the neuromuscular junction." @default.
- W2002142711 created "2016-06-24" @default.
- W2002142711 creator A5004763560 @default.
- W2002142711 creator A5008344839 @default.
- W2002142711 creator A5035781296 @default.
- W2002142711 date "1977-10-01" @default.
- W2002142711 modified "2023-10-18" @default.
- W2002142711 title "Isolation and Characterization of Presynaptically Acting Neurotoxins from the Venom of Bungarus Snakes" @default.
- W2002142711 cites W138546028 @default.
- W2002142711 cites W1484221965 @default.
- W2002142711 cites W1588730657 @default.
- W2002142711 cites W1699965010 @default.
- W2002142711 cites W1967002918 @default.
- W2002142711 cites W1970649364 @default.
- W2002142711 cites W1981755695 @default.
- W2002142711 cites W1983649348 @default.
- W2002142711 cites W2018458802 @default.
- W2002142711 cites W2027985487 @default.
- W2002142711 cites W2043857366 @default.
- W2002142711 cites W2050335943 @default.
- W2002142711 cites W2053413143 @default.
- W2002142711 cites W2054184685 @default.
- W2002142711 cites W2054530577 @default.
- W2002142711 cites W2063456791 @default.
- W2002142711 cites W2073879684 @default.
- W2002142711 cites W2088253874 @default.
- W2002142711 cites W2095105325 @default.
- W2002142711 cites W2119586900 @default.
- W2002142711 cites W2134218003 @default.
- W2002142711 cites W2142272051 @default.
- W2002142711 cites W2159812499 @default.
- W2002142711 doi "https://doi.org/10.1111/j.1432-1033.1977.tb11849.x" @default.
- W2002142711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/303565" @default.
- W2002142711 hasPublicationYear "1977" @default.
- W2002142711 type Work @default.
- W2002142711 sameAs 2002142711 @default.
- W2002142711 citedByCount "201" @default.
- W2002142711 countsByYear W20021427112013 @default.
- W2002142711 countsByYear W20021427112014 @default.
- W2002142711 countsByYear W20021427112015 @default.
- W2002142711 countsByYear W20021427112016 @default.
- W2002142711 countsByYear W20021427112017 @default.
- W2002142711 countsByYear W20021427112018 @default.
- W2002142711 countsByYear W20021427112020 @default.
- W2002142711 countsByYear W20021427112023 @default.
- W2002142711 crossrefType "journal-article" @default.
- W2002142711 hasAuthorship W2002142711A5004763560 @default.
- W2002142711 hasAuthorship W2002142711A5008344839 @default.
- W2002142711 hasAuthorship W2002142711A5035781296 @default.
- W2002142711 hasBestOaLocation W20021427111 @default.
- W2002142711 hasConcept C12927208 @default.
- W2002142711 hasConcept C181199279 @default.
- W2002142711 hasConcept C185592680 @default.
- W2002142711 hasConcept C2776551241 @default.
- W2002142711 hasConcept C2776888444 @default.
- W2002142711 hasConcept C2777367657 @default.
- W2002142711 hasConcept C2779448229 @default.
- W2002142711 hasConcept C2781338088 @default.
- W2002142711 hasConcept C55493867 @default.
- W2002142711 hasConceptScore W2002142711C12927208 @default.
- W2002142711 hasConceptScore W2002142711C181199279 @default.
- W2002142711 hasConceptScore W2002142711C185592680 @default.
- W2002142711 hasConceptScore W2002142711C2776551241 @default.
- W2002142711 hasConceptScore W2002142711C2776888444 @default.
- W2002142711 hasConceptScore W2002142711C2777367657 @default.
- W2002142711 hasConceptScore W2002142711C2779448229 @default.
- W2002142711 hasConceptScore W2002142711C2781338088 @default.
- W2002142711 hasConceptScore W2002142711C55493867 @default.
- W2002142711 hasIssue "1" @default.
- W2002142711 hasLocation W20021427111 @default.
- W2002142711 hasLocation W20021427112 @default.
- W2002142711 hasOpenAccess W2002142711 @default.
- W2002142711 hasPrimaryLocation W20021427111 @default.
- W2002142711 hasRelatedWork W1042387795 @default.
- W2002142711 hasRelatedWork W1978335456 @default.
- W2002142711 hasRelatedWork W2002142711 @default.
- W2002142711 hasRelatedWork W2016548493 @default.
- W2002142711 hasRelatedWork W2041628760 @default.
- W2002142711 hasRelatedWork W2059230502 @default.
- W2002142711 hasRelatedWork W2077340133 @default.
- W2002142711 hasRelatedWork W2176005279 @default.
- W2002142711 hasRelatedWork W2402801613 @default.
- W2002142711 hasRelatedWork W2975155290 @default.
- W2002142711 hasVolume "80" @default.
- W2002142711 isParatext "false" @default.
- W2002142711 isRetracted "false" @default.
- W2002142711 magId "2002142711" @default.
- W2002142711 workType "article" @default.