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- W2002145266 abstract "The extravasation of cancer cells, a key step for distant metastasis, is thought to be initiated by disruption of the endothelial barrier by malignant cancer cells. An endothelial covering-type extravasation of cancer cells in addition to conventional cancer cell invasion-type extravasation was dynamically visualized in a zebrafish hematogenous metastasis model. The inhibition of VEGF-signaling impaired the invasion-type extravasation via inhibition of cancer cell polarization and motility. Paradoxically, the anti-angiogenic treatment showed the promotion, rather than the inhibition, of the endothelial covering-type extravasation of cancer cells, with structural changes in the endothelial walls. These findings may be a set of clues to the full understanding of the metastatic process as well as the metastatic acceleration by anti-angiogenic reagents observed in preclinical studies." @default.
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- W2002145266 date "2014-12-23" @default.
- W2002145266 modified "2023-09-26" @default.
- W2002145266 title "Endothelial cell-initiated extravasation of cancer cells visualized in zebrafish" @default.
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- W2002145266 doi "https://doi.org/10.7717/peerj.688" @default.
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