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- W2002148201 abstract "In order to gain additional information on the hydrophobic bonding region of dihydrofolic reductase, some derivatives of 2, 6-diaminopurine with aryl or aralkyl groups at the N6, C8 and N9-positions were investigated as inhibitors. Since none of the six compounds gave an increment in binding over the parent 2, 6-diaminopurine, hydrophobic bonding to dihydrofolic reductase could not be detected with this ring system. Furthermore, 2, 6-diaminopurine bridged from its 8-position with methylene groups to the amino group of p-aminobenzoic acid also failed to show an increment in binding. The 8-substituted 2, 6-diaminopurines were synthesized by base-catalyzed cyclodehydration of the appropriate 5-acylamido-2, 4, 6-triaminopyrimidines; the latter compounds were readily prepared by selective acylation of tetraaminopyrimidine." @default.
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- W2002148201 date "1967-06-01" @default.
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- W2002148201 title "Irreversible enzyme inhibitors. XCIV. inhibition of dihydrofolic reductase with derivatives of 2,6-diaminopurines" @default.
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- W2002148201 doi "https://doi.org/10.1002/jhet.5570040209" @default.
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