FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002148638> ?p ?o ?g. }

• W2002148638 endingPage "13990" @default.
• W2002148638 startingPage "13981" @default.
• W2002148638 abstract "The urea-induced unfolding reaction of the alpha subunit of tryptophan synthase was monitored by examining the chemical shifts and peak areas of the C epsilon protons of the four histidine residues with 1D NMR spectroscopy. In a native base-line region defined by tyrosine absorbance and far-UV circular dichroism spectroscopy, histidine-146 appears to undergo a rapid, local unfolding reaction at increasing denaturant concentrations. As the native form is converted to a previously detected stable intermediate between 2 and 3 M urea [Matthews, C. R., & Crisanti, M. M. (1981) Biochemistry 20, 784], histidines-92 and -146 in the amino folding unit (residues 1-188) and histidines-195 and -244 in the carboxy folding unit (residues 189-268) all experience a change in their environments which is slow on the NMR time scale. The subsequent conversion of this intermediate to a newly detected, stable, partially folded form populated at 5 M urea appears to have no effect on any of the histidines at 25 degrees C when an intermolecular association process involving His-244 is taken into account. Strikingly, a slow exchange process involving only His-92 is observed to begin at 5 M urea where the unfolding transitions monitored by absorbance or far-UV circular dichroism spectroscopy are essentially complete. This residual tertiary structure unfolds in a cooperative fashion as the urea concentration is increased to 8 M." @default.
• W2002148638 created "2016-06-24" @default.
• W2002148638 creator A5001731159 @default.
• W2002148638 creator A5008485456 @default.
• W2002148638 creator A5017021065 @default.
• W2002148638 date "1993-12-01" @default.
• W2002148638 modified "2023-09-23" @default.
• W2002148638 title "Urea-induced unfolding of the .alpha. subunit of tryptophan synthase: One-dimensional proton NMR evidence for residual structure near histidine-92 at high denaturant concentration" @default.
• W2002148638 cites W1554093892 @default.
• W2002148638 cites W1556499851 @default.
• W2002148638 cites W1568129191 @default.
• W2002148638 cites W1771251144 @default.
• W2002148638 cites W1928528182 @default.
• W2002148638 cites W1976654525 @default.
• W2002148638 cites W1978269053 @default.
• W2002148638 cites W1979763026 @default.
• W2002148638 cites W1988831278 @default.
• W2002148638 cites W1996222219 @default.
• W2002148638 cites W1997475312 @default.
• W2002148638 cites W2000116209 @default.
• W2002148638 cites W2003041624 @default.
• W2002148638 cites W2004455414 @default.
• W2002148638 cites W2016303898 @default.
• W2002148638 cites W2017639307 @default.
• W2002148638 cites W2021529214 @default.
• W2002148638 cites W2021807096 @default.
• W2002148638 cites W2028501050 @default.
• W2002148638 cites W2032846506 @default.
• W2002148638 cites W2036235942 @default.
• W2002148638 cites W2052895607 @default.
• W2002148638 cites W2055118532 @default.
• W2002148638 cites W2067612292 @default.
• W2002148638 cites W2069563872 @default.
• W2002148638 cites W2073553835 @default.
• W2002148638 cites W2082143573 @default.
• W2002148638 cites W2086721085 @default.
• W2002148638 cites W2087717059 @default.
• W2002148638 cites W2088525783 @default.
• W2002148638 cites W2091177185 @default.
• W2002148638 cites W2092045508 @default.
• W2002148638 cites W2107276905 @default.
• W2002148638 cites W2110124895 @default.
• W2002148638 cites W2139327615 @default.
• W2002148638 cites W2172565224 @default.
• W2002148638 cites W2176412414 @default.
• W2002148638 cites W2178040892 @default.
• W2002148638 cites W2313275058 @default.
• W2002148638 cites W2397728113 @default.
• W2002148638 cites W2743163306 @default.
• W2002148638 cites W2888511473 @default.
• W2002148638 doi "https://doi.org/10.1021/bi00213a031" @default.
• W2002148638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8268176" @default.
• W2002148638 hasPublicationYear "1993" @default.
• W2002148638 type Work @default.
• W2002148638 sameAs 2002148638 @default.
• W2002148638 citedByCount "32" @default.
• W2002148638 countsByYear W20021486382012 @default.
• W2002148638 countsByYear W20021486382013 @default.
• W2002148638 countsByYear W20021486382014 @default.
• W2002148638 crossrefType "journal-article" @default.
• W2002148638 hasAuthorship W2002148638A5001731159 @default.
• W2002148638 hasAuthorship W2002148638A5008485456 @default.
• W2002148638 hasAuthorship W2002148638A5017021065 @default.
• W2002148638 hasConcept C111429119 @default.
• W2002148638 hasConcept C119599485 @default.
• W2002148638 hasConcept C127413603 @default.
• W2002148638 hasConcept C133571119 @default.
• W2002148638 hasConcept C13965031 @default.
• W2002148638 hasConcept C147789679 @default.
• W2002148638 hasConcept C185592680 @default.
• W2002148638 hasConcept C204328495 @default.
• W2002148638 hasConcept C2776545253 @default.
• W2002148638 hasConcept C2776706248 @default.
• W2002148638 hasConcept C2776923230 @default.
• W2002148638 hasConcept C2778460671 @default.
• W2002148638 hasConcept C2779882130 @default.
• W2002148638 hasConcept C2780365088 @default.
• W2002148638 hasConcept C43617362 @default.
• W2002148638 hasConcept C515207424 @default.
• W2002148638 hasConcept C55493867 @default.
• W2002148638 hasConcept C66974803 @default.
• W2002148638 hasConcept C71240020 @default.
• W2002148638 hasConcept C8010536 @default.
• W2002148638 hasConcept C98015330 @default.
• W2002148638 hasConceptScore W2002148638C111429119 @default.
• W2002148638 hasConceptScore W2002148638C119599485 @default.
• W2002148638 hasConceptScore W2002148638C127413603 @default.
• W2002148638 hasConceptScore W2002148638C133571119 @default.
• W2002148638 hasConceptScore W2002148638C13965031 @default.
• W2002148638 hasConceptScore W2002148638C147789679 @default.
• W2002148638 hasConceptScore W2002148638C185592680 @default.
• W2002148638 hasConceptScore W2002148638C204328495 @default.
• W2002148638 hasConceptScore W2002148638C2776545253 @default.
• W2002148638 hasConceptScore W2002148638C2776706248 @default.
• W2002148638 hasConceptScore W2002148638C2776923230 @default.
• W2002148638 hasConceptScore W2002148638C2778460671 @default.
• W2002148638 hasConceptScore W2002148638C2779882130 @default.
• W2002148638 hasConceptScore W2002148638C2780365088 @default.

• next