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- W2002151452 abstract "ABSTRACT Background and aim: The deregulation of transforming growth factor β ( TGF‐β ) action and its signaling function has been a widely accepted concept in carcinogenesis. However, its dual roles, as a tumor suppressor gene and oncogene, have interfered in applying TGF‐β signaling to cancer therapeutics. To evaluate its role in the carcinogenesis of oral squamous cell carcinoma (OSCC), we performed mutational analysis of the TGF‐β type II receptor ( TβRII ). Methods: Eighteen cases of OSCC were used for mutational analysis of TβRII . Normal surgical margin, dysplastic lesion, invasive carcinoma and metastatic cancer cells into lymph node tissue were used. Exon‐specific spanning primers of exon 1, 2, 3, 4, 5, 6, 7 of TβRII were used for the mutational analysis. Results: A single nucleotide polymorphism (SNP) at the codon 191 was found in 8 cases. The genetic mutations were mainly found in exon 4 through dysplastic areas, carcinoma and metastatic areas, which induced the structural change or the alteration of hydrophobicity of the amino acid. Conclusions: TβRII mutations occur frequently in exon 4 in OSCC and their functional significance should be proven." @default.
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- W2002151452 date "2009-09-01" @default.
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- W2002151452 title "Genetic mutation of transforming growth factor beta type II receptor in oral squamous cell carcinoma" @default.
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- W2002151452 doi "https://doi.org/10.1111/j.1755-9294.2009.01046.x" @default.
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