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- W2002152170 abstract "Abstract The NMR spectrum of 3′-azido-3′-deoxythymidine (AZT) in aqueous solution provides sum of some of the proton-proton coupling constants. This limitation precludes the determination of the pseudorotational parameters of the sugar ring. Selective deuteration alleviates this problem. The synthesis of 2′-deutero and 3′-deutero- AZT have been described for the first time starting from D-xylose and β-thymidine respectively. NMR study of these analogues in aqueous solutions shows that almost equal amount of C-2′-endo and C-3′-endo species exist in equilibrium." @default.
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- W2002152170 date "1993-01-01" @default.
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- W2002152170 title "Syntheses and conformational studies on AZT and its deuterated analogues" @default.
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- W2002152170 doi "https://doi.org/10.1016/s0040-4020(01)85754-9" @default.
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