Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002156802> ?p ?o ?g. }
- W2002156802 endingPage "671" @default.
- W2002156802 startingPage "653" @default.
- W2002156802 abstract "Glutathione (gamma-glu-cys-gly; GSH) is usually present at high concentrations in most living cells, being the major reservoir of non-protein reduced sulfur. Because of its unique redox and nucleophilic properties, GSH serves in bio-reductive reactions as an important line of defense against reactive oxygen species, xenobiotics and heavy metals. GSH is synthesized from its constituent amino acids by two ATP-dependent reactions catalyzed by gamma-glutamylcysteine synthetase and glutathione synthetase. In yeast, these enzymes are found in the cytosol, whereas in plants they are located in the cytosol and chloroplast. In protists, their location is not well established. In turn, the sulfur assimilation pathway, which leads to cysteine biosynthesis, involves high and low affinity sulfate transporters, and the enzymes ATP sulfurylase, APS kinase, PAPS reductase or APS reductase, sulfite reductase, serine acetyl transferase, O-acetylserine/O-acetylhomoserine sulfhydrylase and, in some organisms, also cystathionine beta-synthase and cystathionine gamma-lyase. The biochemical and genetic regulation of these pathways is affected by oxidative stress, sulfur deficiency and heavy metal exposure. Cells cope with heavy metal stress using different mechanisms, such as complexation and compartmentation. One of these mechanisms in some yeast, plants and protists is the enhanced synthesis of the heavy metal-chelating molecules GSH and phytochelatins, which are formed from GSH by phytochelatin synthase (PCS) in a heavy metal-dependent reaction; Cd(2+) is the most potent activator of PCS. In this work, we review the biochemical and genetic mechanisms involved in the regulation of sulfate assimilation-reduction and GSH metabolism when yeast, plants and protists are challenged by Cd(2+)." @default.
- W2002156802 created "2016-06-24" @default.
- W2002156802 creator A5021751498 @default.
- W2002156802 creator A5023641285 @default.
- W2002156802 creator A5057996372 @default.
- W2002156802 creator A5058452008 @default.
- W2002156802 date "2005-09-01" @default.
- W2002156802 modified "2023-10-16" @default.
- W2002156802 title "Sulfur assimilation and glutathione metabolism under cadmium stress in yeast, protists and plants" @default.
- W2002156802 cites W1490531783 @default.
- W2002156802 cites W1490585409 @default.
- W2002156802 cites W1490837359 @default.
- W2002156802 cites W1495842233 @default.
- W2002156802 cites W1502747560 @default.
- W2002156802 cites W1531373906 @default.
- W2002156802 cites W1551717831 @default.
- W2002156802 cites W1558503775 @default.
- W2002156802 cites W157587617 @default.
- W2002156802 cites W1580892656 @default.
- W2002156802 cites W1591444247 @default.
- W2002156802 cites W1640714761 @default.
- W2002156802 cites W1739310931 @default.
- W2002156802 cites W1784913431 @default.
- W2002156802 cites W1821262099 @default.
- W2002156802 cites W1826309415 @default.
- W2002156802 cites W1847031462 @default.
- W2002156802 cites W1898716493 @default.
- W2002156802 cites W1911807466 @default.
- W2002156802 cites W1964097275 @default.
- W2002156802 cites W1964211632 @default.
- W2002156802 cites W1968472980 @default.
- W2002156802 cites W1971056228 @default.
- W2002156802 cites W1971111302 @default.
- W2002156802 cites W1971948874 @default.
- W2002156802 cites W1973996060 @default.
- W2002156802 cites W1974648961 @default.
- W2002156802 cites W1974726946 @default.
- W2002156802 cites W1979138577 @default.
- W2002156802 cites W1980882362 @default.
- W2002156802 cites W1982615526 @default.
- W2002156802 cites W1982649213 @default.
- W2002156802 cites W1983069156 @default.
- W2002156802 cites W1986372254 @default.
- W2002156802 cites W1990041383 @default.
- W2002156802 cites W1991554522 @default.
- W2002156802 cites W1992823959 @default.
- W2002156802 cites W1994693796 @default.
- W2002156802 cites W1995984362 @default.
- W2002156802 cites W1997405166 @default.
- W2002156802 cites W1999723667 @default.
- W2002156802 cites W1999742975 @default.
- W2002156802 cites W2001013371 @default.
- W2002156802 cites W2001447031 @default.
- W2002156802 cites W2003590441 @default.
- W2002156802 cites W2003627596 @default.
- W2002156802 cites W2003648106 @default.
- W2002156802 cites W2005599767 @default.
- W2002156802 cites W2008520919 @default.
- W2002156802 cites W2009102102 @default.
- W2002156802 cites W2010081336 @default.
- W2002156802 cites W2012268870 @default.
- W2002156802 cites W2012373441 @default.
- W2002156802 cites W2012412357 @default.
- W2002156802 cites W2013320022 @default.
- W2002156802 cites W2014743449 @default.
- W2002156802 cites W2014815091 @default.
- W2002156802 cites W2015618413 @default.
- W2002156802 cites W2017019216 @default.
- W2002156802 cites W2018066181 @default.
- W2002156802 cites W2018119138 @default.
- W2002156802 cites W2019348713 @default.
- W2002156802 cites W2023803983 @default.
- W2002156802 cites W2024376556 @default.
- W2002156802 cites W2025144653 @default.
- W2002156802 cites W2025327528 @default.
- W2002156802 cites W2025374338 @default.
- W2002156802 cites W2025868820 @default.
- W2002156802 cites W2028840350 @default.
- W2002156802 cites W2028997445 @default.
- W2002156802 cites W2030633150 @default.
- W2002156802 cites W2032458072 @default.
- W2002156802 cites W2032648343 @default.
- W2002156802 cites W2035026458 @default.
- W2002156802 cites W2035755182 @default.
- W2002156802 cites W2038142268 @default.
- W2002156802 cites W2041723017 @default.
- W2002156802 cites W2042453798 @default.
- W2002156802 cites W2044944677 @default.
- W2002156802 cites W2049097351 @default.
- W2002156802 cites W2049998464 @default.
- W2002156802 cites W2052374542 @default.
- W2002156802 cites W2053800432 @default.
- W2002156802 cites W2056271095 @default.
- W2002156802 cites W2057865646 @default.
- W2002156802 cites W2058781010 @default.
- W2002156802 cites W2059149158 @default.
- W2002156802 cites W2061358635 @default.
- W2002156802 cites W2063320435 @default.