FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002160745> ?p ?o ?g. }

• W2002160745 endingPage "1557" @default.
• W2002160745 startingPage "1550" @default.
• W2002160745 abstract "Using a polymeric sulfonylurea (PSU) designed from glibenclamide, we examined the interactions of sulfonylurea with pancreatic islets rather than genetically remodeled beta-cell lines to clarify the biological roles of ATP-sensitive K+ (KATP) channels to which sulfonylurea binds. PSU enhanced insulin secretion from the islets with 10 nM (SU equivalent) treatment, especially at low glucose concentration, but its activity was inhibited by 100 microM diazoxide. Confocal microscopy visualized PSU interactions with the islet and revealed that the modulation of intracellular Ca2+ occurred in the same region of an islet where PSU was also bound. In quantification method of the confocal microscopic images, competition of PSU with glibenclamide on its binding sites and glucose inhibition against PSU binding were confirmed. In this study, it was concluded that the PSU was a comparable drug with glibenclamide and offered a new standard method to study intact islets." @default.
• W2002160745 created "2016-06-24" @default.
• W2002160745 creator A5006743557 @default.
• W2002160745 creator A5017364365 @default.
• W2002160745 date "2003-11-01" @default.
• W2002160745 modified "2023-09-23" @default.
• W2002160745 title "Visual Evidence and Quantification of Interaction of Polymeric Sulfonylurea with Pancreatic Islet" @default.
• W2002160745 cites W1958062876 @default.
• W2002160745 cites W1992045485 @default.
• W2002160745 cites W1994924615 @default.
• W2002160745 cites W1996491816 @default.
• W2002160745 cites W2023149007 @default.
• W2002160745 cites W2050051162 @default.
• W2002160745 cites W2053840206 @default.
• W2002160745 cites W2067732699 @default.
• W2002160745 cites W2068108356 @default.
• W2002160745 cites W2070276658 @default.
• W2002160745 cites W2075614798 @default.
• W2002160745 cites W2086849352 @default.
• W2002160745 cites W2088522673 @default.
• W2002160745 cites W2106272975 @default.
• W2002160745 cites W2108027086 @default.
• W2002160745 cites W2110696115 @default.
• W2002160745 cites W2125530988 @default.
• W2002160745 cites W2147843750 @default.
• W2002160745 cites W2161062891 @default.
• W2002160745 cites W2166610424 @default.
• W2002160745 cites W2170772645 @default.
• W2002160745 cites W2172211138 @default.
• W2002160745 cites W2339154093 @default.
• W2002160745 doi "https://doi.org/10.1021/bm025713j" @default.
• W2002160745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14606879" @default.
• W2002160745 hasPublicationYear "2003" @default.
• W2002160745 type Work @default.
• W2002160745 sameAs 2002160745 @default.
• W2002160745 citedByCount "3" @default.
• W2002160745 crossrefType "journal-article" @default.
• W2002160745 hasAuthorship W2002160745A5006743557 @default.
• W2002160745 hasAuthorship W2002160745A5017364365 @default.
• W2002160745 hasConcept C102942909 @default.
• W2002160745 hasConcept C12554922 @default.
• W2002160745 hasConcept C126322002 @default.
• W2002160745 hasConcept C134018914 @default.
• W2002160745 hasConcept C136009344 @default.
• W2002160745 hasConcept C165220095 @default.
• W2002160745 hasConcept C185592680 @default.
• W2002160745 hasConcept C2524010 @default.
• W2002160745 hasConcept C2776828364 @default.
• W2002160745 hasConcept C2778854520 @default.
• W2002160745 hasConcept C2779178360 @default.
• W2002160745 hasConcept C2779306644 @default.
• W2002160745 hasConcept C2779768347 @default.
• W2002160745 hasConcept C2779855799 @default.
• W2002160745 hasConcept C2779872217 @default.
• W2002160745 hasConcept C33923547 @default.
• W2002160745 hasConcept C55493867 @default.
• W2002160745 hasConcept C555293320 @default.
• W2002160745 hasConcept C71924100 @default.
• W2002160745 hasConcept C79879829 @default.
• W2002160745 hasConcept C86803240 @default.
• W2002160745 hasConcept C95444343 @default.
• W2002160745 hasConceptScore W2002160745C102942909 @default.
• W2002160745 hasConceptScore W2002160745C12554922 @default.
• W2002160745 hasConceptScore W2002160745C126322002 @default.
• W2002160745 hasConceptScore W2002160745C134018914 @default.
• W2002160745 hasConceptScore W2002160745C136009344 @default.
• W2002160745 hasConceptScore W2002160745C165220095 @default.
• W2002160745 hasConceptScore W2002160745C185592680 @default.
• W2002160745 hasConceptScore W2002160745C2524010 @default.
• W2002160745 hasConceptScore W2002160745C2776828364 @default.
• W2002160745 hasConceptScore W2002160745C2778854520 @default.
• W2002160745 hasConceptScore W2002160745C2779178360 @default.
• W2002160745 hasConceptScore W2002160745C2779306644 @default.
• W2002160745 hasConceptScore W2002160745C2779768347 @default.
• W2002160745 hasConceptScore W2002160745C2779855799 @default.
• W2002160745 hasConceptScore W2002160745C2779872217 @default.
• W2002160745 hasConceptScore W2002160745C33923547 @default.
• W2002160745 hasConceptScore W2002160745C55493867 @default.
• W2002160745 hasConceptScore W2002160745C555293320 @default.
• W2002160745 hasConceptScore W2002160745C71924100 @default.
• W2002160745 hasConceptScore W2002160745C79879829 @default.
• W2002160745 hasConceptScore W2002160745C86803240 @default.
• W2002160745 hasConceptScore W2002160745C95444343 @default.
• W2002160745 hasIssue "6" @default.
• W2002160745 hasLocation W20021607451 @default.
• W2002160745 hasLocation W20021607452 @default.
• W2002160745 hasOpenAccess W2002160745 @default.
• W2002160745 hasPrimaryLocation W20021607451 @default.
• W2002160745 hasRelatedWork W1973049774 @default.
• W2002160745 hasRelatedWork W1985965417 @default.
• W2002160745 hasRelatedWork W1986775667 @default.
• W2002160745 hasRelatedWork W2002160745 @default.
• W2002160745 hasRelatedWork W2029170600 @default.
• W2002160745 hasRelatedWork W2030768859 @default.
• W2002160745 hasRelatedWork W2064538767 @default.
• W2002160745 hasRelatedWork W2068108356 @default.
• W2002160745 hasRelatedWork W2314005993 @default.
• W2002160745 hasRelatedWork W2411110905 @default.

• next