FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002161005> ?p ?o ?g. }

• W2002161005 endingPage "246" @default.
• W2002161005 startingPage "237" @default.
• W2002161005 abstract "Background: Reciprocal signaling between distinct tissues is a general feature of organogenesis. Despite the identification of developmental processes in which coordination requires reciprocal signaling, little is known regarding the underlying molecular details. Here, we use the development of the uterine–vulval connection in the nematode Caenorhabditis elegans as a model system to study reciprocal signaling.Results: In C. elegans, development of the uterine–vulval connection requires the specification of uterine uv1 cells and morphogenesis of 1°-derived vulval cells. LIN-3, an epidermal growth factor (EGF) family protein, is first produced by the gonadal anchor cell to induce vulval precursor cells to generate vulval tissue. We have shown that lin-3 is also expressed in the 1° vulval lineage after vulval induction and that the 1° vulva is necessary to induce the uv1 uterine cell fate. Using genetic and cell biological analyses, we found that the specification of uterine uv1 cells is dependent on EGF signaling from cells of the 1° vulval lineages to a subset of ventral uterine cells of the gonad. RAS and RAF are necessary for this signaling. We also found that EGL-38, a member of the PAX family of proteins, is necessary for transcription of lin-3 in the vulva but not in the anchor cell. A let-23 mutation that confers ligand-independent activity bypasses the requirement for EGL-38 in specification of the uv1 cell fate.Conclusions: We have shown how relatively simple EGF signals can be used reciprocally to specify the uterine–vulval connection during C. elegans development." @default.
• W2002161005 created "2016-06-24" @default.
• W2002161005 creator A5033624132 @default.
• W2002161005 creator A5053989003 @default.
• W2002161005 creator A5086531214 @default.
• W2002161005 date "1999-03-01" @default.
• W2002161005 modified "2023-09-23" @default.
• W2002161005 title "Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia" @default.
• W2002161005 cites W1757453545 @default.
• W2002161005 cites W1858588370 @default.
• W2002161005 cites W1867554998 @default.
• W2002161005 cites W1874008131 @default.
• W2002161005 cites W1898887078 @default.
• W2002161005 cites W1944127002 @default.
• W2002161005 cites W1946787458 @default.
• W2002161005 cites W1948560580 @default.
• W2002161005 cites W1948927501 @default.
• W2002161005 cites W1969695222 @default.
• W2002161005 cites W1977340628 @default.
• W2002161005 cites W1980073547 @default.
• W2002161005 cites W1986006829 @default.
• W2002161005 cites W1999221590 @default.
• W2002161005 cites W2007962912 @default.
• W2002161005 cites W2008126806 @default.
• W2002161005 cites W2017702115 @default.
• W2002161005 cites W2025782774 @default.
• W2002161005 cites W2033469603 @default.
• W2002161005 cites W2038029561 @default.
• W2002161005 cites W2042106895 @default.
• W2002161005 cites W2048937265 @default.
• W2002161005 cites W2050430335 @default.
• W2002161005 cites W2053753856 @default.
• W2002161005 cites W2055013423 @default.
• W2002161005 cites W2058282339 @default.
• W2002161005 cites W2061920396 @default.
• W2002161005 cites W2062042855 @default.
• W2002161005 cites W2091075863 @default.
• W2002161005 cites W2103842459 @default.
• W2002161005 cites W2104262655 @default.
• W2002161005 cites W2106743120 @default.
• W2002161005 cites W2109781110 @default.
• W2002161005 cites W2110422486 @default.
• W2002161005 cites W2118840188 @default.
• W2002161005 cites W2122163057 @default.
• W2002161005 cites W2126297518 @default.
• W2002161005 cites W2134611436 @default.
• W2002161005 cites W2156981424 @default.
• W2002161005 cites W2168379132 @default.
• W2002161005 cites W2335776432 @default.
• W2002161005 cites W2338755686 @default.
• W2002161005 cites W4229763410 @default.
• W2002161005 doi "https://doi.org/10.1016/s0960-9822(99)80112-2" @default.
• W2002161005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10074449" @default.
• W2002161005 hasPublicationYear "1999" @default.
• W2002161005 type Work @default.
• W2002161005 sameAs 2002161005 @default.
• W2002161005 citedByCount "74" @default.
• W2002161005 countsByYear W20021610052012 @default.
• W2002161005 countsByYear W20021610052013 @default.
• W2002161005 countsByYear W20021610052014 @default.
• W2002161005 countsByYear W20021610052016 @default.
• W2002161005 countsByYear W20021610052017 @default.
• W2002161005 countsByYear W20021610052019 @default.
• W2002161005 countsByYear W20021610052020 @default.
• W2002161005 countsByYear W20021610052021 @default.
• W2002161005 countsByYear W20021610052022 @default.
• W2002161005 crossrefType "journal-article" @default.
• W2002161005 hasAuthorship W2002161005A5033624132 @default.
• W2002161005 hasAuthorship W2002161005A5053989003 @default.
• W2002161005 hasAuthorship W2002161005A5086531214 @default.
• W2002161005 hasBestOaLocation W20021610051 @default.
• W2002161005 hasConcept C104317684 @default.
• W2002161005 hasConcept C124964019 @default.
• W2002161005 hasConcept C138885662 @default.
• W2002161005 hasConcept C142724271 @default.
• W2002161005 hasConcept C145103041 @default.
• W2002161005 hasConcept C148738053 @default.
• W2002161005 hasConcept C1491633281 @default.
• W2002161005 hasConcept C170493617 @default.
• W2002161005 hasConcept C2776316342 @default.
• W2002161005 hasConcept C2776362946 @default.
• W2002161005 hasConcept C2777742833 @default.
• W2002161005 hasConcept C2778944004 @default.
• W2002161005 hasConcept C2780915607 @default.
• W2002161005 hasConcept C2909761498 @default.
• W2002161005 hasConcept C40692019 @default.
• W2002161005 hasConcept C41895202 @default.
• W2002161005 hasConcept C54355233 @default.
• W2002161005 hasConcept C62478195 @default.
• W2002161005 hasConcept C71924100 @default.
• W2002161005 hasConcept C86339819 @default.
• W2002161005 hasConcept C86803240 @default.
• W2002161005 hasConcept C95444343 @default.
• W2002161005 hasConceptScore W2002161005C104317684 @default.
• W2002161005 hasConceptScore W2002161005C124964019 @default.
• W2002161005 hasConceptScore W2002161005C138885662 @default.
• W2002161005 hasConceptScore W2002161005C142724271 @default.
• W2002161005 hasConceptScore W2002161005C145103041 @default.

• next